Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy

Oluwafemi Adeleke Ojo, Olukemi Adetutu Osukoya, Lisa Ilobekemen Ekakitie, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Precious Eseose Agboinghale, Abidemi Paul Kappo

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Gongronema latifolium leaf is used traditionally to treat diabetes and other diseases. The present study aimed to provide the modulatory effect of G. latifolium on hyperglycemia, inhibitory effect of redox imbalance and inflammation in alloxan-induced nephropathy in Wistar rats. Methods: Alloxan monohydrate was used to induce diabetes by an intraperitoneal injection of (150 mg/kg). Three diabetic groups were administered aqueous leaf extract of G. latifolium at 6.36, 12.72 and 25.44 mg/kg bodyweight (BW) respectively; a group was administered with metformin (5 mg/kg BW), while the other two were served as positive and negative control. Thereafter, fasting blood glucose, antioxidant enzymes, malondialdehyde (MDA) level, interleukin 2 and 6 were determined. Results: G. latifolium leaf significantly (p < 0.05) reduced the alloxan-induced increases in blood glucose, MDA, interleukin 2 and interleukin 6 level and increased the alloxan-induced decreases in superoxide dismutase, catalase, glutathione peroxidase, glutathione reduced and glutathione transferase activity. All these changes compared with those of metformin-treated diabetic rats. Conclusion: The data from this study suggest that G. latifolium modulates glucose homeostasis as well as inhibiting redox imbalance and inflammation in diabetic rats, which may be attributed to the effects of its phytochemical constituents such as saponins, flavonoids and alkaloids. It also indicated that inhibition of inflammatory cytokines and redox imbalance are likely mechanisms by which G. latifolium leaf exert its antidiabetic action.

Original languageEnglish
Pages (from-to)469-481
Number of pages13
JournalJournal of Diabetes and Metabolic Disorders
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • And antioxidant activity
  • Diabetic nephropathy
  • Gongronema latifolium
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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