Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine

Dimpo S. Sipuka; Omotayo A. Arotiba; Tsholofelo I. Sebokolodi; Tebogo R. Tsekeli; Duduzile Nkosi

doi:10.1002/elan.202200099

Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine

Dimpo S. Sipuka, Omotayo A. Arotiba, Tsholofelo I. Sebokolodi, Tebogo R. Tsekeli, Duduzile Nkosi

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An electrochemical sensor for dopamine was developed by electrodepositing poly(propylene imine) (PPI) dendrimer and gold nanoparticles (AuNPs) onto a glassy carbon electrode (GCE). Electrochemical characterisation of the sensor was carried out by cyclic voltammetry and electrochemical impedance spectroscopy in ferri/ferrocyanide electrolyte. The nanocomposite electrode (GCE-PPI-AuNPs) showed improved electroactive surface area and electrochemical response over bare GCE. The sensor recorded a detection limit of 0.16 μM over a concentration range of 0.1 μM to 125 μM. The sensor was applied for dopamine detection in human serum samples and in the presence of interfering substances such as ascorbic acid and epinephrine.

Original language	English
Article number	e202200099
Journal	Electroanalysis
Volume	35
Issue number	3
DOIs	https://doi.org/10.1002/elan.202200099
Publication status	Published - Mar 2023

Keywords

dopamine
electrochemical sensor
gold nanoparticles
poly (propylene imine) dendrimer
square wave voltammetry

ASJC Scopus subject areas

Analytical Chemistry
Electrochemistry

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10.1002/elan.202200099

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title = "Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine",

abstract = "An electrochemical sensor for dopamine was developed by electrodepositing poly(propylene imine) (PPI) dendrimer and gold nanoparticles (AuNPs) onto a glassy carbon electrode (GCE). Electrochemical characterisation of the sensor was carried out by cyclic voltammetry and electrochemical impedance spectroscopy in ferri/ferrocyanide electrolyte. The nanocomposite electrode (GCE-PPI-AuNPs) showed improved electroactive surface area and electrochemical response over bare GCE. The sensor recorded a detection limit of 0.16 μM over a concentration range of 0.1 μM to 125 μM. The sensor was applied for dopamine detection in human serum samples and in the presence of interfering substances such as ascorbic acid and epinephrine.",

keywords = "dopamine, electrochemical sensor, gold nanoparticles, poly (propylene imine) dendrimer, square wave voltammetry",

author = "Sipuka, {Dimpo S.} and Arotiba, {Omotayo A.} and Sebokolodi, {Tsholofelo I.} and Tsekeli, {Tebogo R.} and Duduzile Nkosi",

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doi = "10.1002/elan.202200099",

language = "English",

volume = "35",

journal = "Electroanalysis",

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T1 - Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine

AU - Sipuka, Dimpo S.

AU - Arotiba, Omotayo A.

AU - Sebokolodi, Tsholofelo I.

AU - Tsekeli, Tebogo R.

AU - Nkosi, Duduzile

PY - 2023/3

Y1 - 2023/3

N2 - An electrochemical sensor for dopamine was developed by electrodepositing poly(propylene imine) (PPI) dendrimer and gold nanoparticles (AuNPs) onto a glassy carbon electrode (GCE). Electrochemical characterisation of the sensor was carried out by cyclic voltammetry and electrochemical impedance spectroscopy in ferri/ferrocyanide electrolyte. The nanocomposite electrode (GCE-PPI-AuNPs) showed improved electroactive surface area and electrochemical response over bare GCE. The sensor recorded a detection limit of 0.16 μM over a concentration range of 0.1 μM to 125 μM. The sensor was applied for dopamine detection in human serum samples and in the presence of interfering substances such as ascorbic acid and epinephrine.

AB - An electrochemical sensor for dopamine was developed by electrodepositing poly(propylene imine) (PPI) dendrimer and gold nanoparticles (AuNPs) onto a glassy carbon electrode (GCE). Electrochemical characterisation of the sensor was carried out by cyclic voltammetry and electrochemical impedance spectroscopy in ferri/ferrocyanide electrolyte. The nanocomposite electrode (GCE-PPI-AuNPs) showed improved electroactive surface area and electrochemical response over bare GCE. The sensor recorded a detection limit of 0.16 μM over a concentration range of 0.1 μM to 125 μM. The sensor was applied for dopamine detection in human serum samples and in the presence of interfering substances such as ascorbic acid and epinephrine.

KW - dopamine

KW - electrochemical sensor

KW - gold nanoparticles

KW - poly (propylene imine) dendrimer

KW - square wave voltammetry

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DO - 10.1002/elan.202200099

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JF - Electroanalysis

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ER -

Gold-dendrimer Nanocomposite Based Electrochemical Sensor for Dopamine

Abstract

Keywords

ASJC Scopus subject areas

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