Glyco disulfide capped gold nanoparticle synthesis: Cytotoxicity studies and effects on lung cancer A549 cells

Christian K. Adokoh; Frankline K. Keter; Collins Obuah; Henok H. Kinfe; Robert Tshikhudo; James Darkwa

doi:10.4155/fmc-2021-0165

Glyco disulfide capped gold nanoparticle synthesis: Cytotoxicity studies and effects on lung cancer A549 cells

Christian K. Adokoh
, Frankline K. Keter
, Collins Obuah
, Henok H. Kinfe
, Robert Tshikhudo
, James Darkwa

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.

Original language	English
Pages (from-to)	307-324
Number of pages	18
Journal	Future Medicinal Chemistry
Volume	14
Issue number	5
DOIs	https://doi.org/10.4155/fmc-2021-0165
Publication status	Published - Mar 2022

Keywords

D-(+)-gluconic acid δ-lactone
amino alkyl thiol
anticancer
glyco disulfide
glyco nanoparticles

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4155/fmc-2021-0165

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@article{79842c1425e8497cb4c763e1677d22b3,

title = "Glyco disulfide capped gold nanoparticle synthesis: Cytotoxicity studies and effects on lung cancer A549 cells",

abstract = "Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.",

keywords = "D-(+)-gluconic acid δ-lactone, amino alkyl thiol, anticancer, glyco disulfide, glyco nanoparticles",

author = "Adokoh, \{Christian K.\} and Keter, \{Frankline K.\} and Collins Obuah and Kinfe, \{Henok H.\} and Robert Tshikhudo and James Darkwa",

note = "Publisher Copyright: {\textcopyright} 2022 Newlands Press.",

year = "2022",

month = mar,

doi = "10.4155/fmc-2021-0165",

language = "English",

volume = "14",

pages = "307--324",

journal = "Future Medicinal Chemistry",

issn = "1756-8919",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Glyco disulfide capped gold nanoparticle synthesis

T2 - Cytotoxicity studies and effects on lung cancer A549 cells

AU - Adokoh, Christian K.

AU - Keter, Frankline K.

AU - Obuah, Collins

AU - Kinfe, Henok H.

AU - Tshikhudo, Robert

AU - Darkwa, James

PY - 2022/3

Y1 - 2022/3

N2 - Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.

AB - Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.

KW - D-(+)-gluconic acid δ-lactone

KW - amino alkyl thiol

KW - anticancer

KW - glyco disulfide

KW - glyco nanoparticles

UR - https://www.scopus.com/pages/publications/85125211796

U2 - 10.4155/fmc-2021-0165

DO - 10.4155/fmc-2021-0165

M3 - Article

C2 - 35050694

AN - SCOPUS:85125211796

SN - 1756-8919

VL - 14

SP - 307

EP - 324

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

IS - 5

ER -

Glyco disulfide capped gold nanoparticle synthesis: Cytotoxicity studies and effects on lung cancer A549 cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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