Abstract
Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.
Original language | English |
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Pages (from-to) | 307-324 |
Number of pages | 18 |
Journal | Future Medicinal Chemistry |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2022 |
Keywords
- D-(+)-gluconic acid δ-lactone
- amino alkyl thiol
- anticancer
- glyco disulfide
- glyco nanoparticles
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery