Glyco disulfide capped gold nanoparticle synthesis: Cytotoxicity studies and effects on lung cancer A549 cells

Christian K. Adokoh, Frankline K. Keter, Collins Obuah, Henok H. Kinfe, Robert Tshikhudo, James Darkwa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Glyco disulfide gold nanoparticles (GDAuNPs) were prepared by three methods: direct, photochemical irradiation and ligand substitution. Glyco disulfide acted as reducing and capping agents of gold ions, to produce AuNPs GD1-GD16. Results: Shorter chains of glyco disulfides (n = 1 and 2) offered monodispersed and stable GDAuNPs in physiological pH, while longer chains (n = 3) furnished unstable nanoparticles. ζ-potential study of direct method GDAuNPs revealed surface charge dependency on the alkyl unit length. Transmission electron microscope imaging indicated that sizes/shapes of the ligand exchange AuNPs remained post-exchange step. The mechanism of GDAuNP formation was forecast as the Ostwald ripening effect at low pH of ligand (5.1-8.9) and reinforcement of static stabilization at high pH (12.4-13.0). Conclusion: GDAuNPs recorded moderately anticancer activity against the A549 cancer cell line, with IC50 between 14.95 and 64.95 μg/ml.

Original languageEnglish
Pages (from-to)307-324
Number of pages18
JournalFuture Medicinal Chemistry
Volume14
Issue number5
DOIs
Publication statusPublished - Mar 2022

Keywords

  • D-(+)-gluconic acid δ-lactone
  • amino alkyl thiol
  • anticancer
  • glyco disulfide
  • glyco nanoparticles

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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