Gelatin stabilization of quantum dots for improved stability and biocompatibility

Sundararajan Parani, Kannaiyan Pandian, Oluwatobi Samuel Oluwafemi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


We herein report an aqueous synthesis of gelatin stabilized CdTe/CdS/ZnS (CSSG) core/double shell quantum dots (QDs) with improved biocompatibility. The as-synthesized QDs were characterized by ultraviolet-visible (UV–vis) and photoluminescence (PL) spectroscopic techniques, x-ray diffraction technique (XRD), x-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The CSSG QDs revealed high photoluminescence quantum yield (PLQY) with excellent stability over a period of one year and retained 90% of its initial PLQY without any aggregation or precipitation under ambient condition. The cell viability study conducted on HeLa, cervical cancer cell lines indicated that the gelatin stabilization effectively decreased the QDs cytotoxicity by about 50%. The CSSG QDs were conjugated with transferrin (Tf) for the efficient delivery to the cancer cells followed by fluorescence imaging. The results showed that the CSSG QDs illuminates the entire cell which renders the QDs as cell labeling markers. The gelatin stabilized core/double shell QDs are potential candidates for long time fluorescent bio-imaging.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalInternational Journal of Biological Macromolecules
Issue numberPartA
Publication statusPublished - Feb 2018


  • Cytotoxicity
  • Gelatin
  • Quantum dots

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • General Energy


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