Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine

Narendra Pal Singh Chauhan; Behnaz Ashtari; Behnaz Sadat Eftekhari; Masoud Akhshik; Hanna J. Maria; Sadjad Khosravimelal; Nicholas Seifalian; Sabu Thomas; Mazaher Gholipourmalekabadi; Alexander M. Seifalian

doi:10.1016/j.bioadv.2025.214421

Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine

Narendra Pal Singh Chauhan, Behnaz Ashtari, Behnaz Sadat Eftekhari, Masoud Akhshik, Hanna J. Maria, Sadjad Khosravimelal, Nicholas Seifalian, Sabu Thomas, Mazaher Gholipourmalekabadi, Alexander M. Seifalian

Research output: Contribution to journal › Review article › peer-review

Abstract

The unique physical and chemical characteristics of graphene oxide (GO) have recently attracted great attention, which highlighted its potential as a promising material for electronic, industrial, biomedical and others potential applications. GO has several functional groups of oxygen, which makes it easier to make GO dispersed in aqueous solution insulating in nature. The functionalization and surface modification of GO is one of the strategies that recently attracted much attention for various electrochemical and biological applications. In general overview, for the functionalization of GO surface, some methods have been proposed that make it possible for the GO-based materials and electrodes for various applications. This comprehensive review focuses on the promising characteristics and recent advances in the functionalization of GO, benefits and limitations, for regenerative medicine and tissue engineering applications.

Original language	English
Article number	214421
Journal	Biomaterials Advances
Volume	178
DOIs	https://doi.org/10.1016/j.bioadv.2025.214421
Publication status	Published - Jan 2026
Externally published	Yes

Keywords

Biofunctionalization
Biomedicine
Functionalization
Graphene
Graphene oxide
Human organs
Nanomaterial
Nanoparticle
Regenerative medicine
Surgical implants
Tissue engineering

ASJC Scopus subject areas

Bioengineering
Biomaterials
Biomedical Engineering

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10.1016/j.bioadv.2025.214421

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title = "Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine",

abstract = "The unique physical and chemical characteristics of graphene oxide (GO) have recently attracted great attention, which highlighted its potential as a promising material for electronic, industrial, biomedical and others potential applications. GO has several functional groups of oxygen, which makes it easier to make GO dispersed in aqueous solution insulating in nature. The functionalization and surface modification of GO is one of the strategies that recently attracted much attention for various electrochemical and biological applications. In general overview, for the functionalization of GO surface, some methods have been proposed that make it possible for the GO-based materials and electrodes for various applications. This comprehensive review focuses on the promising characteristics and recent advances in the functionalization of GO, benefits and limitations, for regenerative medicine and tissue engineering applications.",

keywords = "Biofunctionalization, Biomedicine, Functionalization, Graphene, Graphene oxide, Human organs, Nanomaterial, Nanoparticle, Regenerative medicine, Surgical implants, Tissue engineering",

author = "Chauhan, \{Narendra Pal Singh\} and Behnaz Ashtari and Eftekhari, \{Behnaz Sadat\} and Masoud Akhshik and Maria, \{Hanna J.\} and Sadjad Khosravimelal and Nicholas Seifalian and Sabu Thomas and Mazaher Gholipourmalekabadi and Seifalian, \{Alexander M.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2026",

month = jan,

doi = "10.1016/j.bioadv.2025.214421",

language = "English",

volume = "178",

journal = "Biomaterials Advances",

issn = "2772-9508",

publisher = "Elsevier Ltd.",

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T1 - Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine

AU - Chauhan, Narendra Pal Singh

AU - Ashtari, Behnaz

AU - Eftekhari, Behnaz Sadat

AU - Akhshik, Masoud

AU - Maria, Hanna J.

AU - Khosravimelal, Sadjad

AU - Seifalian, Nicholas

AU - Thomas, Sabu

AU - Gholipourmalekabadi, Mazaher

AU - Seifalian, Alexander M.

PY - 2026/1

Y1 - 2026/1

N2 - The unique physical and chemical characteristics of graphene oxide (GO) have recently attracted great attention, which highlighted its potential as a promising material for electronic, industrial, biomedical and others potential applications. GO has several functional groups of oxygen, which makes it easier to make GO dispersed in aqueous solution insulating in nature. The functionalization and surface modification of GO is one of the strategies that recently attracted much attention for various electrochemical and biological applications. In general overview, for the functionalization of GO surface, some methods have been proposed that make it possible for the GO-based materials and electrodes for various applications. This comprehensive review focuses on the promising characteristics and recent advances in the functionalization of GO, benefits and limitations, for regenerative medicine and tissue engineering applications.

AB - The unique physical and chemical characteristics of graphene oxide (GO) have recently attracted great attention, which highlighted its potential as a promising material for electronic, industrial, biomedical and others potential applications. GO has several functional groups of oxygen, which makes it easier to make GO dispersed in aqueous solution insulating in nature. The functionalization and surface modification of GO is one of the strategies that recently attracted much attention for various electrochemical and biological applications. In general overview, for the functionalization of GO surface, some methods have been proposed that make it possible for the GO-based materials and electrodes for various applications. This comprehensive review focuses on the promising characteristics and recent advances in the functionalization of GO, benefits and limitations, for regenerative medicine and tissue engineering applications.

KW - Biofunctionalization

KW - Biomedicine

KW - Functionalization

KW - Graphene

KW - Graphene oxide

KW - Human organs

KW - Nanomaterial

KW - Nanoparticle

KW - Regenerative medicine

KW - Surgical implants

KW - Tissue engineering

UR - https://www.scopus.com/pages/publications/105012366780

U2 - 10.1016/j.bioadv.2025.214421

DO - 10.1016/j.bioadv.2025.214421

M3 - Review article

C2 - 40752075

AN - SCOPUS:105012366780

SN - 2772-9508

VL - 178

JO - Biomaterials Advances

JF - Biomaterials Advances

M1 - 214421

ER -

Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

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