Flavanones from the stem bark of Erythrina abyssinica

Long Cui; Phuong Thien Thuong; Hyun Sun Lee; Derek Tantoh Ndinteh; Joseph Tanyi Mbafor; Zacharias Tanee Fomum; Won Keun Oh

doi:10.1016/j.bmc.2008.10.012

Flavanones from the stem bark of Erythrina abyssinica

Long Cui, Phuong Thien Thuong, Hyun Sun Lee, Derek Tantoh Ndinteh, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Won Keun Oh

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC₅₀ values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. Crown

Original language	English
Pages (from-to)	10356-10362
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	24
DOIs	https://doi.org/10.1016/j.bmc.2008.10.012
Publication status	Published - 15 Dec 2008
Externally published	Yes

Keywords

2,2-Dimethylpyrano ring
Erythrina abyssinica
Flavanone
PTP1B inhibitor

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2008.10.012

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title = "Flavanones from the stem bark of Erythrina abyssinica",

abstract = "Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. Crown",

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author = "Long Cui and Thuong, \{Phuong Thien\} and Lee, \{Hyun Sun\} and Ndinteh, \{Derek Tantoh\} and Mbafor, \{Joseph Tanyi\} and Fomum, \{Zacharias Tanee\} and Oh, \{Won Keun\}",

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T1 - Flavanones from the stem bark of Erythrina abyssinica

AU - Cui, Long

AU - Thuong, Phuong Thien

AU - Lee, Hyun Sun

AU - Ndinteh, Derek Tantoh

AU - Mbafor, Joseph Tanyi

AU - Fomum, Zacharias Tanee

AU - Oh, Won Keun

PY - 2008/12/15

Y1 - 2008/12/15

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AB - Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B. Crown

KW - 2,2-Dimethylpyrano ring

KW - Erythrina abyssinica

KW - Flavanone

KW - PTP1B inhibitor

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M3 - Article

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AN - SCOPUS:56349152852

SN - 0968-0896

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EP - 10362

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

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ER -

Flavanones from the stem bark of Erythrina abyssinica

Abstract

Keywords

ASJC Scopus subject areas

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