Fate of haem iron in the malaria parasite Plasmodium falciparum

Timothy J. Egan; Jill M. Combrinck; Joanne Egan; Giovanni R. Hearne; Helder M. Marques; Skhumbuzo Ntenteni; B. Trevor Sewell; Peter J. Smith; Dale Taylor; Donelly A. Van Schalkwyk; Jason C. Walden

doi:10.1042/BJ20020793

Fate of haem iron in the malaria parasite Plasmodium falciparum

Timothy J. Egan
, Jill M. Combrinck
, Joanne Egan
, Giovanni R. Hearne
, Helder M. Marques
, Skhumbuzo Ntenteni
, B. Trevor Sewell
, Peter J. Smith
, Dale Taylor
, Donelly A. Van Schalkwyk
, Jason C. Walden

Research output: Contribution to journal › Article › peer-review

254 Citations (Scopus)

Abstract

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. ⁵⁷Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	Biochemical Journal
Volume	365
Issue number	2
DOIs	https://doi.org/10.1042/BJ20020793
Publication status	Published - 15 Jul 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Electron spectroscopic imaging
Haemozoin
Mössbauer spectroscopy

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1042/BJ20020793

Cite this

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title = "Fate of haem iron in the malaria parasite Plasmodium falciparum",

abstract = "Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2\% of the iron within parasitized erythrocytes, of which 92±6\% is located within the food vacuole. Of this, 88±9\% is in the form of haemozoin. 57Fe- M{\"o}ssbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.",

keywords = "Electron spectroscopic imaging, Haemozoin, M{\"o}ssbauer spectroscopy",

author = "Egan, \{Timothy J.\} and Combrinck, \{Jill M.\} and Joanne Egan and Hearne, \{Giovanni R.\} and Marques, \{Helder M.\} and Skhumbuzo Ntenteni and Sewell, \{B. Trevor\} and Smith, \{Peter J.\} and Dale Taylor and \{Van Schalkwyk\}, \{Donelly A.\} and Walden, \{Jason C.\}",

year = "2002",

month = jul,

day = "15",

doi = "10.1042/BJ20020793",

language = "English",

volume = "365",

pages = "343--347",

journal = "Biochemical Journal",

issn = "0264-6021",

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TY - JOUR

T1 - Fate of haem iron in the malaria parasite Plasmodium falciparum

AU - Egan, Timothy J.

AU - Combrinck, Jill M.

AU - Egan, Joanne

AU - Hearne, Giovanni R.

AU - Marques, Helder M.

AU - Ntenteni, Skhumbuzo

AU - Sewell, B. Trevor

AU - Smith, Peter J.

AU - Taylor, Dale

AU - Van Schalkwyk, Donelly A.

AU - Walden, Jason C.

PY - 2002/7/15

Y1 - 2002/7/15

N2 - Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

AB - Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

KW - Electron spectroscopic imaging

KW - Haemozoin

KW - Mössbauer spectroscopy

UR - https://www.scopus.com/pages/publications/0037101785

U2 - 10.1042/BJ20020793

DO - 10.1042/BJ20020793

M3 - Article

C2 - 12033986

AN - SCOPUS:0037101785

SN - 0264-6021

VL - 365

SP - 343

EP - 347

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

Fate of haem iron in the malaria parasite Plasmodium falciparum

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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