Fate of haem iron in the malaria parasite Plasmodium falciparum

Timothy J. Egan; Jill M. Combrinck; Joanne Egan; Giovanni R. Hearne; Helder M. Marques; Skhumbuzo Ntenteni; B. Trevor Sewell; Peter J. Smith; Dale Taylor; Donelly A. Van Schalkwyk; Jason C. Walden

doi:10.1042/BJ20020793

Fate of haem iron in the malaria parasite Plasmodium falciparum

Timothy J. Egan, Jill M. Combrinck, Joanne Egan, Giovanni R. Hearne, Helder M. Marques, Skhumbuzo Ntenteni, B. Trevor Sewell, Peter J. Smith, Dale Taylor, Donelly A. Van Schalkwyk, Jason C. Walden

Research output: Contribution to journal › Article › peer-review

249 Citations (Scopus)

Abstract

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. ⁵⁷Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	Biochemical Journal
Volume	365
Issue number	2
DOIs	https://doi.org/10.1042/BJ20020793
Publication status	Published - 15 Jul 2002
Externally published	Yes

Keywords

Electron spectroscopic imaging
Haemozoin
Mössbauer spectroscopy

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/BJ20020793

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title = "Fate of haem iron in the malaria parasite Plasmodium falciparum",

abstract = "Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2\% of the iron within parasitized erythrocytes, of which 92±6\% is located within the food vacuole. Of this, 88±9\% is in the form of haemozoin. 57Fe- M{\"o}ssbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.",

keywords = "Electron spectroscopic imaging, Haemozoin, M{\"o}ssbauer spectroscopy",

author = "Egan, \{Timothy J.\} and Combrinck, \{Jill M.\} and Joanne Egan and Hearne, \{Giovanni R.\} and Marques, \{Helder M.\} and Skhumbuzo Ntenteni and Sewell, \{B. Trevor\} and Smith, \{Peter J.\} and Dale Taylor and \{Van Schalkwyk\}, \{Donelly A.\} and Walden, \{Jason C.\}",

year = "2002",

month = jul,

day = "15",

doi = "10.1042/BJ20020793",

language = "English",

volume = "365",

pages = "343--347",

journal = "Biochemical Journal",

issn = "0264-6021",

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TY - JOUR

T1 - Fate of haem iron in the malaria parasite Plasmodium falciparum

AU - Egan, Timothy J.

AU - Combrinck, Jill M.

AU - Egan, Joanne

AU - Hearne, Giovanni R.

AU - Marques, Helder M.

AU - Ntenteni, Skhumbuzo

AU - Sewell, B. Trevor

AU - Smith, Peter J.

AU - Taylor, Dale

AU - Van Schalkwyk, Donelly A.

AU - Walden, Jason C.

PY - 2002/7/15

Y1 - 2002/7/15

N2 - Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

AB - Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe- Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

KW - Electron spectroscopic imaging

KW - Haemozoin

KW - Mössbauer spectroscopy

UR - https://www.scopus.com/pages/publications/0037101785

U2 - 10.1042/BJ20020793

DO - 10.1042/BJ20020793

M3 - Article

C2 - 12033986

AN - SCOPUS:0037101785

SN - 0264-6021

VL - 365

SP - 343

EP - 347

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

Fate of haem iron in the malaria parasite Plasmodium falciparum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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