Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus

F. J. Van Schalkwyk, M. A. Stander, M. Nsizwane, A. Mathee, B. E. Van Wyk

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described.

Original languageEnglish
Article number110680
JournalForensic Science International
Volume320
DOIs
Publication statusPublished - Mar 2021

Keywords

  • LCMS
  • Pyrrolizidine alkaloids
  • Retrorsine-N-oxide
  • Senecio coronatus
  • Traditional medicine
  • UPLC-MS/MS

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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