Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy

Olayemi J. Fakayode; Sandile P. Songca; Oluwatobi S. Oluwafemi

doi:10.1007/978-3-319-51493-2_3

Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy

Olayemi J. Fakayode
, Sandile P. Songca
, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Porphyrin has been proven to be an efficient photosensitizer for photodynamic therapy (PDT). However, the problem of undesired localization in non-tumour environments has lowered its therapeutic efficacy. To make porphyrin tumour specific, we have successfully conjugated a meso-substituted symmetric 4-hydroxyphenyl porphyrin (THPP) to superparamagnetic iron oxide nanoparticles-gold core-shell nanostructure (SPIONs-Au). The magnetic porphyrin conjugate (MPC) was characterized using UV-Visible spectrophotometry (UV-Vis), Photoluminescence spectroscopy (PL) and Fourier Transform infrared spectroscopy (FT-IR). The as-synthesized MPC exhibited strong attraction towards external magnetic field and high singlet oxygen quantum yield sufficient for the eradication of cancer cells in vitro.

Original language	English
Title of host publication	TMS 2017 146th Annual Meeting
Publisher	Springer International Publishing
Pages	23-27
Number of pages	5
ISBN (Print)	9783319514925
DOIs	https://doi.org/10.1007/978-3-319-51493-2_3
Publication status	Published - 2017
Event	146th Annual Meeting and Exhibition Supplemental, TMS 2017 - San Diego, United States Duration: 26 Feb 2017 → 2 Mar 2017

Publication series

Name	Minerals, Metals and Materials Series
Volume	Part F6
ISSN (Print)	2367-1181
ISSN (Electronic)	2367-1696

Conference

Conference	146th Annual Meeting and Exhibition Supplemental, TMS 2017
Country/Territory	United States
City	San Diego
Period	26/02/17 → 2/03/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Gold
Magnetic targeting
PDT
Porphyrin
SPIONs

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Energy Engineering and Power Technology
Mechanics of Materials
Metals and Alloys
Materials Chemistry

Access to Document

10.1007/978-3-319-51493-2_3

Cite this

Fakayode, O. J., Songca, S. P., & Oluwafemi, O. S. (2017). Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy. In TMS 2017 146th Annual Meeting (pp. 23-27). (Minerals, Metals and Materials Series; Vol. Part F6). Springer International Publishing. https://doi.org/10.1007/978-3-319-51493-2_3

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title = "Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy",

abstract = "Porphyrin has been proven to be an efficient photosensitizer for photodynamic therapy (PDT). However, the problem of undesired localization in non-tumour environments has lowered its therapeutic efficacy. To make porphyrin tumour specific, we have successfully conjugated a meso-substituted symmetric 4-hydroxyphenyl porphyrin (THPP) to superparamagnetic iron oxide nanoparticles-gold core-shell nanostructure (SPIONs-Au). The magnetic porphyrin conjugate (MPC) was characterized using UV-Visible spectrophotometry (UV-Vis), Photoluminescence spectroscopy (PL) and Fourier Transform infrared spectroscopy (FT-IR). The as-synthesized MPC exhibited strong attraction towards external magnetic field and high singlet oxygen quantum yield sufficient for the eradication of cancer cells in vitro.",

keywords = "Breast cancer, Gold, Magnetic targeting, PDT, Porphyrin, SPIONs",

author = "Fakayode, \{Olayemi J.\} and Songca, \{Sandile P.\} and Oluwafemi, \{Oluwatobi S.\}",

note = "Publisher Copyright: {\textcopyright} The Minerals, Metals \& Materials Society 2017.; 146th Annual Meeting and Exhibition Supplemental, TMS 2017 ; Conference date: 26-02-2017 Through 02-03-2017",

year = "2017",

doi = "10.1007/978-3-319-51493-2\_3",

language = "English",

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Fakayode, OJ, Songca, SP & Oluwafemi, OS 2017, Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy. in TMS 2017 146th Annual Meeting. Minerals, Metals and Materials Series, vol. Part F6, Springer International Publishing, pp. 23-27, 146th Annual Meeting and Exhibition Supplemental, TMS 2017, San Diego, United States, 26/02/17. https://doi.org/10.1007/978-3-319-51493-2_3

Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy. / Fakayode, Olayemi J.; Songca, Sandile P.; Oluwafemi, Oluwatobi S.
TMS 2017 146th Annual Meeting. Springer International Publishing, 2017. p. 23-27 (Minerals, Metals and Materials Series; Vol. Part F6).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy

AU - Fakayode, Olayemi J.

AU - Songca, Sandile P.

AU - Oluwafemi, Oluwatobi S.

N1 - Publisher Copyright: © The Minerals, Metals & Materials Society 2017.

PY - 2017

Y1 - 2017

N2 - Porphyrin has been proven to be an efficient photosensitizer for photodynamic therapy (PDT). However, the problem of undesired localization in non-tumour environments has lowered its therapeutic efficacy. To make porphyrin tumour specific, we have successfully conjugated a meso-substituted symmetric 4-hydroxyphenyl porphyrin (THPP) to superparamagnetic iron oxide nanoparticles-gold core-shell nanostructure (SPIONs-Au). The magnetic porphyrin conjugate (MPC) was characterized using UV-Visible spectrophotometry (UV-Vis), Photoluminescence spectroscopy (PL) and Fourier Transform infrared spectroscopy (FT-IR). The as-synthesized MPC exhibited strong attraction towards external magnetic field and high singlet oxygen quantum yield sufficient for the eradication of cancer cells in vitro.

AB - Porphyrin has been proven to be an efficient photosensitizer for photodynamic therapy (PDT). However, the problem of undesired localization in non-tumour environments has lowered its therapeutic efficacy. To make porphyrin tumour specific, we have successfully conjugated a meso-substituted symmetric 4-hydroxyphenyl porphyrin (THPP) to superparamagnetic iron oxide nanoparticles-gold core-shell nanostructure (SPIONs-Au). The magnetic porphyrin conjugate (MPC) was characterized using UV-Visible spectrophotometry (UV-Vis), Photoluminescence spectroscopy (PL) and Fourier Transform infrared spectroscopy (FT-IR). The as-synthesized MPC exhibited strong attraction towards external magnetic field and high singlet oxygen quantum yield sufficient for the eradication of cancer cells in vitro.

KW - Breast cancer

KW - Gold

KW - Magnetic targeting

KW - PDT

KW - Porphyrin

KW - SPIONs

UR - https://www.scopus.com/pages/publications/85042371756

U2 - 10.1007/978-3-319-51493-2_3

DO - 10.1007/978-3-319-51493-2_3

M3 - Conference contribution

AN - SCOPUS:85042371756

SN - 9783319514925

T3 - Minerals, Metals and Materials Series

SP - 23

EP - 27

BT - TMS 2017 146th Annual Meeting

PB - Springer International Publishing

T2 - 146th Annual Meeting and Exhibition Supplemental, TMS 2017

Y2 - 26 February 2017 through 2 March 2017

ER -

Facile green synthesis and characterization of water soluble superparamagnetic iron oxide-gold porphyrin conjugate for improved photodynamic therapy

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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