@inproceedings{0886d4580fe44930874180ad019a3cc8,
title = "Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications",
abstract = "Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.",
keywords = "Chitosan, Montmorillonite, Nanocomposites, Polylactide, Scaffolds, Tissue engineering",
author = "Mkhabela, {Vuyiswa J.} and Ray, {Suprakas Sinha}",
note = "Publisher Copyright: {\textcopyright} 2015 AIP Publishing LLC.; 30th International Conference of the Polymer Processing Society, PPS 2014 ; Conference date: 06-06-2014 Through 12-06-2014",
year = "2015",
month = may,
day = "22",
doi = "10.1063/1.4918444",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Jana, {Sadhan C.}",
booktitle = "Proceedings of PPS-30",
}