Fabrication of polylactide nanocomposite scaffolds for bone tissue engineering applications

Vuyiswa J. Mkhabela, Suprakas Sinha Ray

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Highly porous three-dimensional polylactide (PLA) scaffolds were obtained from PLA incorporated with different amounts of chitosan-modified montmorillonite (CS-MMT), through solvent casting and particulate leaching method. The processed scaffolds were tested in vitro for their possible application in bone tissue engineering. Scaffolds were characterized by Focused Ion Beam Scanning Electron Microscopy (FIB SEM), Fourier Transform Infra-Red (FTIR), and X-Ray Diffraction (XRD) to study their structure and intermolecular interactions. Bioresorbability tests in simulated body fluid (pH 7.4) were conducted to assess the response of the scaffolds in a simulated physiological condition. The FIB SEM images of the scaffolds showed a porous architecture with gradual change in morphology with increasing CS-MMT concentration. FTIR analysis revealed the presence of both PLA and CS-MMT particles on the surface of the scaffolds. XRD showed that the crystalline unit cell type was the same for all the scaffolds, and crystallinity decreased with an increase in CS-MMT concentration. The scaffolds were found to be bioresorbable, with rapid bioresorbability on the scaffolds with a high CS-MMT concentration.

Original languageEnglish
Title of host publicationProceedings of PPS-30
Subtitle of host publicationThe 30th International Conference of the Polymer Processing Society - Conference Papers
EditorsSadhan C. Jana
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413092
DOIs
Publication statusPublished - 22 May 2015
Event30th International Conference of the Polymer Processing Society, PPS 2014 - Cleveland, United States
Duration: 6 Jun 201412 Jun 2014

Publication series

NameAIP Conference Proceedings
Volume1664
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference30th International Conference of the Polymer Processing Society, PPS 2014
Country/TerritoryUnited States
CityCleveland
Period6/06/1412/06/14

Keywords

  • Chitosan
  • Montmorillonite
  • Nanocomposites
  • Polylactide
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • General Physics and Astronomy

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