Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview

Nastaran Hadizadeh, Diba Bagheri, Mehdi Shamsara, Michael R. Hamblin, Abbas Farmany, Mengdi Xu, Zhuobin Liang, Farideh Razi, Ehsan Hashemi

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

The main goals of medicine consist of early detection and effective treatment of different diseases. In this regard, the rise of exosomes as carriers of natural biomarkers has recently attracted a lot of attention and managed to shed more light on the future of early disease diagnosis methods. Here, exosome biogenesis, its role as a biomarker in metabolic disorders, and recent advances in state-of-art technologies for exosome detection and isolation will be reviewed along with future research directions and challenges regarding the manipulation and genetic engineering of exosomes for potential in vitro and in vivo disease diagnosis approaches.

Original languageEnglish
Article number1019821
JournalFrontiers in Bioengineering and Biotechnology
Volume10
DOIs
Publication statusPublished - 4 Nov 2022
Externally publishedYes

Keywords

  • Exosome
  • biogenesis
  • extracellular vesicles
  • manipulation
  • therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

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