TY - GEN
T1 - Exploring the Therapeutic Potential of Cannabis Sativa
T2 - 2nd International Conference on Futuristic Materials for Sustainable Development Goals, FMSDG 2025
AU - Avoseh, Folajimi T.
AU - Takaidza, Samkeliso
AU - Erukainure, Ochuko L.
AU - Avoseh, Opeyemi N.
AU - Mtunzi, Fanyana M.
AU - Nkhi, Mpho G.
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2026.
PY - 2026
Y1 - 2026
N2 - Cannabis sativa L. is increasingly recognized for its therapeutic potential beyond its psychoactive properties and use in fiber production. Recent research highlights its efficacy in treating pain, anxiety, inflammation, and as an antioxidant. These benefits are attributed to a variety of bioactive compounds, including cannabinoids, terpenes, and flavonoids, which have sparked interest in their medicinal applications. This study investigated the phytochemical composition and biological activities of two C. sativa strains, with a particular focus on identifying functional groups using FTIR. Crude extracts from C. sativa buds were prepared using solvents of varying polarities. Phytochemical contents were quantified using standard techniques. Antioxidant activity was measured via TLC, DPPH, and FRAP assays, while antimicrobial activity was assessed using the agar well diffusion method. FTIR analysis was used to detect functional groups in the extracts. Phytochemical analysis showed TPC values ranging from 11.77 to 93.51 mg GAE/g and TFC values from 25.61 to 45.95 mg QE/g. The ethyl acetate extract (high THC) exhibited the highest TPC (93.5 mg GAE/g) and a DPPH IC50 of 0.0065 µg/L, indicating strong antioxidant activity. Cheese 2 extracts (ethanolic and n-hexane) showed higher TFC values (45.95 & 45.59 mg QE/g). TLC confirmed antioxidant activity. The DPPH assay confirmed strong radical scavenging activity, while FRAP displayed notable activities in neutralizing free radicals. Both strains displayed notable antimicrobial activity against E. coli, S. aureus, B. cereus, and S. typhi. FTIR analysis identified key functional groups related to cannabinoids, terpenes, and fatty acids. These findings highlight C. sativa as a promising source of bioactive compounds with antioxidant and antimicrobial properties. However, further research is needed to fully assess its antioxidant potential.
AB - Cannabis sativa L. is increasingly recognized for its therapeutic potential beyond its psychoactive properties and use in fiber production. Recent research highlights its efficacy in treating pain, anxiety, inflammation, and as an antioxidant. These benefits are attributed to a variety of bioactive compounds, including cannabinoids, terpenes, and flavonoids, which have sparked interest in their medicinal applications. This study investigated the phytochemical composition and biological activities of two C. sativa strains, with a particular focus on identifying functional groups using FTIR. Crude extracts from C. sativa buds were prepared using solvents of varying polarities. Phytochemical contents were quantified using standard techniques. Antioxidant activity was measured via TLC, DPPH, and FRAP assays, while antimicrobial activity was assessed using the agar well diffusion method. FTIR analysis was used to detect functional groups in the extracts. Phytochemical analysis showed TPC values ranging from 11.77 to 93.51 mg GAE/g and TFC values from 25.61 to 45.95 mg QE/g. The ethyl acetate extract (high THC) exhibited the highest TPC (93.5 mg GAE/g) and a DPPH IC50 of 0.0065 µg/L, indicating strong antioxidant activity. Cheese 2 extracts (ethanolic and n-hexane) showed higher TFC values (45.95 & 45.59 mg QE/g). TLC confirmed antioxidant activity. The DPPH assay confirmed strong radical scavenging activity, while FRAP displayed notable activities in neutralizing free radicals. Both strains displayed notable antimicrobial activity against E. coli, S. aureus, B. cereus, and S. typhi. FTIR analysis identified key functional groups related to cannabinoids, terpenes, and fatty acids. These findings highlight C. sativa as a promising source of bioactive compounds with antioxidant and antimicrobial properties. However, further research is needed to fully assess its antioxidant potential.
KW - Antimicrobial
KW - Antioxidant
KW - Bioactive compounds
KW - Cannabis sativa
KW - Phytochemistry
UR - https://www.scopus.com/pages/publications/105036805069
U2 - 10.1007/978-981-95-1991-0_2
DO - 10.1007/978-981-95-1991-0_2
M3 - Conference contribution
AN - SCOPUS:105036805069
SN - 9789819519903
T3 - Springer Proceedings in Physics
SP - 23
EP - 43
BT - Proceedings of the 2nd International Conference on Futuristic Materials for Sustainable Development Goals - FMSDG 2025
A2 - Modise, Sekomeng Johannes
A2 - Mlambo, Mbuso
A2 - Pholosi, Agnes
A2 - Bambo, Mokae
A2 - Mtshatsheni, Kgomotso N. G.
A2 - Mokhena, Teboho Clement
A2 - Dlamini, Langelihle
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 6 April 2025 through 9 April 2025
ER -