Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Liyi Huang; Lun Ma; Weijun Xuan; Xiumei Zhen; Han Zheng; Wei Chen; Michael R. Hamblin

doi:10.1166/jbn.2019.2829

Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Liyi Huang, Lun Ma, Weijun Xuan, Xiumei Zhen, Han Zheng, Wei Chen, Michael R. Hamblin

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

Original language	English
Pages (from-to)	2142-2148
Number of pages	7
Journal	Journal of Biomedical Nanotechnology
Volume	15
Issue number	10
DOIs	https://doi.org/10.1166/jbn.2019.2829
Publication status	Published - 2019
Externally published	Yes

Keywords

Antimicrobial photodynamic inactivation
Copper-cysteamine nanoparticles
Gram-negative bacteria
Gram-positive bacteria
Reactive oxygen species

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/jbn.2019.2829

Cite this

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title = "Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation",

abstract = "Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.",

keywords = "Antimicrobial photodynamic inactivation, Copper-cysteamine nanoparticles, Gram-negative bacteria, Gram-positive bacteria, Reactive oxygen species",

author = "Liyi Huang and Lun Ma and Weijun Xuan and Xiumei Zhen and Han Zheng and Wei Chen and Hamblin, {Michael R.}",

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year = "2019",

doi = "10.1166/jbn.2019.2829",

language = "English",

volume = "15",

pages = "2142--2148",

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TY - JOUR

T1 - Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

AU - Huang, Liyi

AU - Ma, Lun

AU - Xuan, Weijun

AU - Zhen, Xiumei

AU - Zheng, Han

AU - Chen, Wei

AU - Hamblin, Michael R.

PY - 2019

Y1 - 2019

N2 - Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

AB - Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

KW - Antimicrobial photodynamic inactivation

KW - Copper-cysteamine nanoparticles

KW - Gram-negative bacteria

KW - Gram-positive bacteria

KW - Reactive oxygen species

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U2 - 10.1166/jbn.2019.2829

DO - 10.1166/jbn.2019.2829

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SN - 1550-7033

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SP - 2142

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Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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