Exosomal miRNAs: Novel players in viral infection

Javid Sadri Nahand; Maryam Mahjoubin-Tehran; Mohsen Moghoofei; Mohammad Hossein Pourhanifeh; Hamid Reza Mirzaei; Zatollah Asemi; Alireza Khatami; Farah Bokharaei-Salim; Hamed Mirzaei; Michael R. Hamblin

doi:10.2217/epi-2019-0192

Exosomal miRNAs: Novel players in viral infection

Javid Sadri Nahand, Maryam Mahjoubin-Tehran, Mohsen Moghoofei, Mohammad Hossein Pourhanifeh, Hamid Reza Mirzaei, Zatollah Asemi, Alireza Khatami, Farah Bokharaei-Salim, Hamed Mirzaei, Michael R. Hamblin

Research output: Contribution to journal › Review article › peer-review

61 Citations (Scopus)

Abstract

Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

Original language	English
Pages (from-to)	353-370
Number of pages	18
Journal	Epigenomics
Volume	12
Issue number	4
DOIs	https://doi.org/10.2217/epi-2019-0192
Publication status	Published - Feb 2020
Externally published	Yes

Keywords

diagnostic biomarkers
exosomes
host response
miRNAs
therapeutic targets
viral infections

ASJC Scopus subject areas

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2019-0192

Cite this

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abstract = "Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.",

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doi = "10.2217/epi-2019-0192",

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volume = "12",

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AU - Nahand, Javid Sadri

AU - Mahjoubin-Tehran, Maryam

AU - Moghoofei, Mohsen

AU - Pourhanifeh, Mohammad Hossein

AU - Mirzaei, Hamid Reza

AU - Asemi, Zatollah

AU - Khatami, Alireza

AU - Bokharaei-Salim, Farah

AU - Mirzaei, Hamed

AU - Hamblin, Michael R.

PY - 2020/2

Y1 - 2020/2

N2 - Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

AB - Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.

KW - diagnostic biomarkers

KW - exosomes

KW - host response

KW - miRNAs

KW - therapeutic targets

KW - viral infections

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EP - 370

JO - Epigenomics

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Exosomal miRNAs: Novel players in viral infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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