TY - JOUR
T1 - Exosomal microRNAs derived from mesenchymal stem cells
T2 - Cell-to-cell messages
AU - Asgarpour, Kasra
AU - Shojaei, Zahra
AU - Amiri, Fatemeh
AU - Ai, Jafar
AU - Mahjoubin-Tehran, Maryam
AU - Ghasemi, Faezeh
AU - Arefnezhad, Reza
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/9/11
Y1 - 2020/9/11
N2 - Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. [MediaObject not available: see fulltext.]
AB - Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. [MediaObject not available: see fulltext.]
KW - Exosomes
KW - Mesenchymal stem cells
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=85090889551&partnerID=8YFLogxK
U2 - 10.1186/s12964-020-00650-6
DO - 10.1186/s12964-020-00650-6
M3 - Review article
C2 - 32917227
AN - SCOPUS:85090889551
SN - 1478-811X
VL - 18
JO - Cell Communication and Signaling
JF - Cell Communication and Signaling
IS - 1
M1 - 149
ER -