Exosomal microRNAs and exosomal long non-coding RNAs in gynecologic cancers

Maryam Hashemipour, Homa Boroumand, Samaneh Mollazadeh, Vida Tajiknia, Zahra Nourollahzadeh, Mina Rohani Borj, Hossein Pourghadamyari, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)

Abstract

Gynecologic cancer is a group of any malignancies affecting reproductive tissues and organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium. Several types of molecular mechanisms are associated with the progression of gynecologic cancers. Among it can be referred to the most widely studied non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) and long ncRNAs (lncRNAs). As yet, lncRNAs are known to serve key biological roles via various mechanisms, such as splicing regulation, chromatin rearrangement, translation regulation, cell-cycle control, genetic imprinting and mRNA decay. Besides, miRNAs govern gene expression by modulation of mRNAs and lncRNAs degradation, suggestive of needing more research in this field. Generally, driving gynecological cancers pathways by miRNAs and lncRNAs lead to the current improvement in cancer-related technologies. Exosomes are extracellular microvesicles which can carry cargo molecules among cells. In recent years, more studies have been focused on exosomal non-coding RNAs (exo-ncRNAs) and exosomal microRNAs (exo-miRs) because of being natural carriers of lnc RNAs and microRNAs via programmed process. In this review we summarized recent reports concerning the function of exosomal microRNAs and exosomal long non-coding RNAs in gynecological cancers.

Original languageEnglish
Pages (from-to)314-327
Number of pages14
JournalGynecologic Oncology
Volume161
Issue number1
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Exosome
  • Gynecologic cancers
  • Long non-coding RNAs
  • MicroRNAs

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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