Abstract
Objectives: The present investigation has been undertaken to study the antioxidant and analgesic potential of Rubus fairholmianus. Materials and methods: The leaf, stem and root of the plant were extracted successively in Soxhlet and subjected to quantification (total phenolics, tannins and flavonoids) and in vitro antioxidant assays such as ABTS, phosphomolybdenum, metal chelating, nitric oxide and super oxide radical scavenging assays. R. fairholmianus root acetone extract (RFRA) was tested for the analgesic property using acetic acid induced model. Results: The RFRA depicted higher content in the quantification of total phenolics and flavonoids. The radical scavenging assays such as ABTS, phosphomolybdenum, metal chelating, nitric oxide and super oxide radical scavenging assays possess good activity. 200 and 400 mg/kg of RFRA showed significant activities for analgesic activity in acetic acid induced model. RFRA extracts higher dose showed superior activity compared to lower dose. Conclusion: This study could suggest that the use of R. fairholmianus as a valuable natural antioxidant, analgesic drug and has immense scope as an effective source to fight against the free radical generated diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 484-488 |
| Number of pages | 5 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 5 |
| Issue number | SUPPL 3 |
| Publication status | Published - 2013 |
| Externally published | Yes |
Keywords
- Acute toxicity
- Analgesic
- Free radicals
- Phenolics
- Rubus fairholmianus
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science