Electrochemical detection of amoxicillin on 2D graphene-gold nanoparticle-Lacasse bio-interfaces: Combined experimental and theoretical study

Adeniyi Olugbenga Osikoya; Francis Opoku; Penny Poomani Govender

doi:10.1016/j.cplett.2020.138278

Electrochemical detection of amoxicillin on 2D graphene-gold nanoparticle-Lacasse bio-interfaces: Combined experimental and theoretical study

Adeniyi Olugbenga Osikoya, Francis Opoku, Penny Poomani Govender

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

In this study, using self-assembly and electrostatic interactions we developed a sensitive 2D graphene-gold nanoparticles nanocomposite. Morphological and structural characterization confirmed the presence of crystalline 2D sp² hybridized graphitic carbon material. The fabricated interface materials displayed fast electrocatalytic response to increasing molar addition of amoxicillin with linear detection range (LDR) from 4,25 × 10⁻¹ µM – 2,92 × 10² µM while 4,25 × 10⁻¹ µM is the detection limit (LoD) and the sensitivity was found to be 2,04 × 10³ µA/µMcm⁻² for GCE/Gr/AuNP/Lac fabricated bioelectrode. DFT calculations were used to determine the most stable amoxicillin configuration on Gr/AuNP electrode surface.

Original language	English
Article number	138278
Journal	Chemical Physics Letters
Volume	764
DOIs	https://doi.org/10.1016/j.cplett.2020.138278
Publication status	Published - Feb 2021

Keywords

2D-materials
Amoxicillin
Antibiotic
DFT
Electrochemical biosensor
Gold nanoparticles
Graphene
Raman spectroscopy
XRD

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1016/j.cplett.2020.138278

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title = "Electrochemical detection of amoxicillin on 2D graphene-gold nanoparticle-Lacasse bio-interfaces: Combined experimental and theoretical study",

abstract = "In this study, using self-assembly and electrostatic interactions we developed a sensitive 2D graphene-gold nanoparticles nanocomposite. Morphological and structural characterization confirmed the presence of crystalline 2D sp2 hybridized graphitic carbon material. The fabricated interface materials displayed fast electrocatalytic response to increasing molar addition of amoxicillin with linear detection range (LDR) from 4,25 × 10−1 µM – 2,92 × 102 µM while 4,25 × 10−1 µM is the detection limit (LoD) and the sensitivity was found to be 2,04 × 103 µA/µMcm−2 for GCE/Gr/AuNP/Lac fabricated bioelectrode. DFT calculations were used to determine the most stable amoxicillin configuration on Gr/AuNP electrode surface.",

keywords = "2D-materials, Amoxicillin, Antibiotic, DFT, Electrochemical biosensor, Gold nanoparticles, Graphene, Raman spectroscopy, XRD",

author = "Osikoya, {Adeniyi Olugbenga} and Francis Opoku and Govender, {Penny Poomani}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = feb,

doi = "10.1016/j.cplett.2020.138278",

language = "English",

volume = "764",

journal = "Chemical Physics Letters",

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T2 - Combined experimental and theoretical study

AU - Osikoya, Adeniyi Olugbenga

AU - Opoku, Francis

AU - Govender, Penny Poomani

PY - 2021/2

Y1 - 2021/2

N2 - In this study, using self-assembly and electrostatic interactions we developed a sensitive 2D graphene-gold nanoparticles nanocomposite. Morphological and structural characterization confirmed the presence of crystalline 2D sp2 hybridized graphitic carbon material. The fabricated interface materials displayed fast electrocatalytic response to increasing molar addition of amoxicillin with linear detection range (LDR) from 4,25 × 10−1 µM – 2,92 × 102 µM while 4,25 × 10−1 µM is the detection limit (LoD) and the sensitivity was found to be 2,04 × 103 µA/µMcm−2 for GCE/Gr/AuNP/Lac fabricated bioelectrode. DFT calculations were used to determine the most stable amoxicillin configuration on Gr/AuNP electrode surface.

AB - In this study, using self-assembly and electrostatic interactions we developed a sensitive 2D graphene-gold nanoparticles nanocomposite. Morphological and structural characterization confirmed the presence of crystalline 2D sp2 hybridized graphitic carbon material. The fabricated interface materials displayed fast electrocatalytic response to increasing molar addition of amoxicillin with linear detection range (LDR) from 4,25 × 10−1 µM – 2,92 × 102 µM while 4,25 × 10−1 µM is the detection limit (LoD) and the sensitivity was found to be 2,04 × 103 µA/µMcm−2 for GCE/Gr/AuNP/Lac fabricated bioelectrode. DFT calculations were used to determine the most stable amoxicillin configuration on Gr/AuNP electrode surface.

KW - 2D-materials

KW - Amoxicillin

KW - Antibiotic

KW - DFT

KW - Electrochemical biosensor

KW - Gold nanoparticles

KW - Graphene

KW - Raman spectroscopy

KW - XRD

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DO - 10.1016/j.cplett.2020.138278

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JF - Chemical Physics Letters

M1 - 138278

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Electrochemical detection of amoxicillin on 2D graphene-gold nanoparticle-Lacasse bio-interfaces: Combined experimental and theoretical study

Abstract

Keywords

ASJC Scopus subject areas

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