Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Pemmatte A. Pushpanjali, Jamballi G. Manjunatha, Nagarajappa Hareesha, Ammar M. Tighezza, Munirah D. Albaqami, Mika Sillanpää

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

An inexpensive and efficient sensor was developed for the electrochemical analysis of the antihistamine drug cetirizine (CTZ). The active sites on the bare carbon nanotube paste electrode surface were improved by the electropolymerization of poly(Glutamine). This modified electrode enhances the electrochemical response of the examining molecule. The study was conducted using a cyclic voltammetry technique in phosphate buffer saline of physiological pH 7.0 at a scan rate of 0.1 V/s. The developed electrode possesses increased conductance and declined overpotential for the determination of CTZ. At the optimized conditions, the detection limit was evaluated by obtaining the current response of CTZ at the varied concentration, and it was obtained as 0.12 μM. The poly glutamine modified carbon nanotube paste electrode was successfully applied to determine CTZ in tablet and human urine samples with acceptable recovery.

Original languageEnglish
Article numbere202300818
JournalChemistrySelect
Volume8
Issue number31
DOIs
Publication statusPublished - 18 Aug 2023
Externally publishedYes

Keywords

  • Carbon nanotubes
  • Cetirizine
  • Cyclic voltammetry
  • Paracetamol
  • poly(glutamine)

ASJC Scopus subject areas

  • General Chemistry

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