Efficient Synthesis of Dihydropyrimidines Using a Highly Ordered Mesoporous Functionalized Pyridinium Organosilica

Fatemeh Rajabi, Mika Sillanpää, Christophe Len, Rafael Luque

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A Brönsted acidic ionic solid pyridinium-functionalized organosilica network (PMO-Py-IL) was demonstrated to efficiently catalyse one-pot Biginelli condensation reaction. The green synthesis of 3,4-dihydro-2(H)-pyrimidinones (DHPMs) with high yield was carried out via one-pot three component condensation of β-dicarbonyls, aldehydes, and urea in the presence of a catalytic amount of PMO-Py-IL nanomaterial as an efficient nanocatalyst under solvent free conditions. Furthermore, the catalyst showed outstanding stability and could be easily separated and reused for at least ten reaction runs without significant loss of activity and product selectivity. The green protocol features simple set-up, cost-effectiveness, easy work-up, eco-friendly and mild reaction conditions.

Original languageEnglish
Article number350
JournalCatalysts
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2022
Externally publishedYes

Keywords

  • Biginelli reaction
  • Dihydropyrimidines
  • Pyridinium-functionalized organosilica
  • Reusable nanocatalyst

ASJC Scopus subject areas

  • Catalysis
  • General Environmental Science
  • Physical and Theoretical Chemistry

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