TY - JOUR
T1 - Effects of therapeutic probiotics on modulation of microRNAs
AU - Davoodvandi, Amirhossein
AU - Marzban, Havva
AU - Goleij, Pouya
AU - Sahebkar, Amirhossein
AU - Morshedi, Korosh
AU - Rezaei, Samaneh
AU - Mahjoubin-Tehran, Maryam
AU - Tarrahimofrad, Hossein
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential beneficial impact on human health. Probiotics compete with pathogenic microorganisms for adhesion sites within the gut, to antagonize them or to regulate the host immune response resulting in preventive and therapeutic effects. Therefore, dysbiosis, defined as an impairment in the gut microbiota, could play a role in various pathological conditions, such as lactose intolerance, gastrointestinal and urogenital infections, various cancers, cystic fibrosis, allergies, inflammatory bowel disease, and can also be caused by antibiotic side effects. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate gene expression in a post-transcriptional manner. miRNAs are biochemical biomarkers that play an important role in almost all cellular signaling pathways in many healthy and disease states. For the first time, the present review summarizes current evidence suggesting that the beneficial properties of probiotics could be explained based on the pivotal role of miRNAs. [MediaObject not available: see fulltext.]
AB - Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential beneficial impact on human health. Probiotics compete with pathogenic microorganisms for adhesion sites within the gut, to antagonize them or to regulate the host immune response resulting in preventive and therapeutic effects. Therefore, dysbiosis, defined as an impairment in the gut microbiota, could play a role in various pathological conditions, such as lactose intolerance, gastrointestinal and urogenital infections, various cancers, cystic fibrosis, allergies, inflammatory bowel disease, and can also be caused by antibiotic side effects. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate gene expression in a post-transcriptional manner. miRNAs are biochemical biomarkers that play an important role in almost all cellular signaling pathways in many healthy and disease states. For the first time, the present review summarizes current evidence suggesting that the beneficial properties of probiotics could be explained based on the pivotal role of miRNAs. [MediaObject not available: see fulltext.]
KW - Biomarkers
KW - Cancer
KW - Inflammatory bowel disease
KW - MicroRNAs
KW - Probiotics
KW - Supplements
UR - http://www.scopus.com/inward/record.url?scp=85099261310&partnerID=8YFLogxK
U2 - 10.1186/s12964-020-00668-w
DO - 10.1186/s12964-020-00668-w
M3 - Review article
C2 - 33430873
AN - SCOPUS:85099261310
SN - 1478-811X
VL - 19
JO - Cell Communication and Signaling
JF - Cell Communication and Signaling
IS - 1
M1 - 4
ER -