Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double-blind, randomized controlled clinical trial

Frederico Carlos Jana Neto, Ana Luiza Cabrera Martimbianco, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Gustavo Porto Alves, Paulo Victor Dias Almeida, Felipe Guimaraes Delgado, Lucas Resende Fonseca, Maiara Zeni Graiff Gama, Mariana Djrdjrjan Jorge, Michael R. Hamblin, Kristianne Porta Santos Fernandes

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This study evaluated the efficacy and safety of multiwavelength photobiomodulation (MPBM) in healing soft tissue injuries associated with tibial and/or ankle fractures. Participants were randomized into the MPBM or control group. Primary outcome was wound healing, measured by the Bates-Jensen scale. Assessments were performed daily. Twenty-seven hospitalized adults were included. MPBM showed an improvement in the daily mean Bates-Jensen scale (MPBM 32.1 vs. control 34.2; p = 0.029), daily mean pain score change (MPBM 0.5 vs. control 0.2; p = 0.04) and occurrence of infection at the site of the external fixator pins (MPBM 15.3% vs. control 57.1%; p = 0.02). MPBM group also showed faster-wound resolution (MPBM 13.1 vs. control 23.1 days). Subgroup analysis showed improvement in the MPBM group among less severe patients on the Bates-Jensen scale (MPBM 27.4 vs. control 34.7; p = 0.0081) and mean time for wound resolution (MPBM 7.0 vs. control 14.6 days; p = 0.03). MPBM appears safe and effective in reducing wound resolution time, infection in the surgical pin sites, reported pain and time before definitive surgery.

Original languageEnglish
Article numbere202200299
JournalJournal of Biophotonics
Volume16
Issue number5
DOIs
Publication statusPublished - May 2023

Keywords

  • bone fracture
  • multiwavelength LED
  • non-pharmaceutical pain control
  • photobiomodulation
  • randomized placebo-controlled clinical trial

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • General Biochemistry,Genetics and Molecular Biology
  • General Engineering
  • General Physics and Astronomy

Fingerprint

Dive into the research topics of 'Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double-blind, randomized controlled clinical trial'. Together they form a unique fingerprint.

Cite this