Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

Sara Ahmadpour; Tarannomsadat Taghavi; Amirhossein Sheida; Seyed Saeed Tamehri Zadeh; Michael R. Hamblin; Hamed Mirzaei

doi:10.2217/epi-2021-0439

Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Hamed Mirzaei

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.

Original language	English
Pages (from-to)	549-563
Number of pages	15
Journal	Epigenomics
Volume	14
Issue number	9
DOIs	https://doi.org/10.2217/epi-2021-0439
Publication status	Published - May 2022

Keywords

Chemotherapy
Glioma
Long non-coding RNAs
Radiotherapy
microRNAs

ASJC Scopus subject areas

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2021-0439

Cite this

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title = "Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma",

abstract = "Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.",

keywords = "Chemotherapy, Glioma, Long non-coding RNAs, Radiotherapy, microRNAs",

author = "Sara Ahmadpour and Tarannomsadat Taghavi and Amirhossein Sheida and {Tamehri Zadeh}, {Seyed Saeed} and Hamblin, {Michael R.} and Hamed Mirzaei",

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language = "English",

volume = "14",

pages = "549--563",

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T1 - Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

AU - Ahmadpour, Sara

AU - Taghavi, Tarannomsadat

AU - Sheida, Amirhossein

AU - Tamehri Zadeh, Seyed Saeed

AU - Hamblin, Michael R.

AU - Mirzaei, Hamed

PY - 2022/5

Y1 - 2022/5

N2 - Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.

AB - Glioma is the most prevalent invasive primary tumor of the central nervous system. Glioma cells can spread and infiltrate into normal surrounding brain tissues. Despite the standard use of chemotherapy and radiotherapy after surgery in glioma patients, treatment resistance is still a problem, as the underlying mechanisms are still not fully understood. Non-coding RNAs are widely involved in tumor progression and treatment resistance mechanisms. In the present review, we discuss the pathways by which microRNAs and long non-coding RNAs can affect resistance to chemotherapy and radiotherapy, as well as offer potential therapeutic options for future glioma treatment.

KW - Chemotherapy

KW - Glioma

KW - Long non-coding RNAs

KW - Radiotherapy

KW - microRNAs

UR - http://www.scopus.com/inward/record.url?scp=85130533632&partnerID=8YFLogxK

U2 - 10.2217/epi-2021-0439

DO - 10.2217/epi-2021-0439

M3 - Review article

C2 - 35473299

AN - SCOPUS:85130533632

SN - 1750-1911

VL - 14

SP - 549

EP - 563

JO - Epigenomics

JF - Epigenomics

IS - 9

ER -

Effects of microRNAs and long non-coding RNAs on chemotherapy response in glioma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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