Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

Niloofar Haeri Moghaddam; Somayeh Hashamdar; Michael R. Hamblin; Fatemeh Ramezani

doi:10.1016/j.wneu.2023.10.065

Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

Niloofar Haeri Moghaddam, Somayeh Hashamdar, Michael R. Hamblin, Fatemeh Ramezani

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Nanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this meta-analysis study, we investigated the effect of these nanofibers on the motor function of animals after SCI. An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and β-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.

Original language	English
Pages (from-to)	96-106
Number of pages	11
Journal	World Neurosurgery
Volume	181
DOIs	https://doi.org/10.1016/j.wneu.2023.10.065
Publication status	Published - Jan 2024

Keywords

Animal models
Electrospinning
Functional recovery
GFAP
Neurofilament-200
Polymeric nanofibers
Spinal cord injury

ASJC Scopus subject areas

Surgery
Neurology (clinical)

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10.1016/j.wneu.2023.10.065

Cite this

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title = "Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis",

abstract = "Nanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this meta-analysis study, we investigated the effect of these nanofibers on the motor function of animals after SCI. An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and β-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.",

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AU - Hamblin, Michael R.

AU - Ramezani, Fatemeh

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AB - Nanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this meta-analysis study, we investigated the effect of these nanofibers on the motor function of animals after SCI. An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and β-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.

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Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

Abstract

Keywords

ASJC Scopus subject areas

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