Effects of Electrospun Nanofibers on Motor Function Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

Niloofar Haeri Moghaddam, Somayeh Hashamdar, Michael R. Hamblin, Fatemeh Ramezani

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Nanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this meta-analysis study, we investigated the effect of these nanofibers on the motor function of animals after SCI. An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and β-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.

Original languageEnglish
Pages (from-to)96-106
Number of pages11
JournalWorld Neurosurgery
Volume181
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Animal models
  • Electrospinning
  • Functional recovery
  • GFAP
  • Neurofilament-200
  • Polymeric nanofibers
  • Spinal cord injury

ASJC Scopus subject areas

  • Surgery
  • Neurology (clinical)

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