Abstract
Objective: To investigate the ability of the methanolic extract of pineapple peel to attenuate alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues. Methods: Oxidative stress was induced by oral administration of ethanol (20% w/v) at a dosage of 5 mL/kg bw in rats. After 28 days of treatment, the rats were fasted overnight and sacrificed by cervical dislocation. Brain tissues were assayed for total phospholipid (TP) content and malondialdehyde (MDA). Results: Administration of alcohol significantly caused a reduction in TP content. Treatment with pineapple peel extract significantly increased the TP content. Significant high levels of MDA was observed in alcohol-fed rats, treatment with pineapple peel extract significantly reduced the MDA levels. Conclusions: Results obtained from this study indicates that pineapple peel extract protects against alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 182-184 |
| Number of pages | 3 |
| Journal | Asian Pacific Journal of Tropical Medicine |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
| Externally published | Yes |
Keywords
- Alcohol
- Brain
- Malondialdehyde
- Total phospholipids
ASJC Scopus subject areas
- General Medicine