Effect of photobiomodulation on cellular migration and survival in diabetic and hypoxic diabetic wounded fibroblast cells

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8 Citations (Scopus)

Abstract

A disrupted wound repair process often leads to the development of chronic wounds, and pose a major physical, social and economic inconvenience on patients and the public health sector. Chronic wounds are a common complication seen in diabetes mellitus (DM), and often the severity necessitates amputation of the lower limbs. Recently, there has been increasing evidence that photobiomodulation (PBM) initiates wound healing, including increased protein transcription for cell proliferation, viability, migration and tissue reepithelialisation. Here, the hypothesis that PBM at a wavelength of 660 nm and energy density of 5 J/cm2 regulates wound repair in diabetic wounded and hypoxic diabetic wounded fibroblasts by enhancing cell migration and survival was investigated. PBM increased migration and survival in diabetic wounded and hypoxic diabetic wounded fibroblasts. Our findings suggest that PBM enhances migration and survival in diabetic wounded and hypoxic diabetic wounded fibroblasts, indicating that this therapeutic method may be beneficial against chronic wounds in diabetic patients.

Original languageEnglish
Pages (from-to)365-374
Number of pages10
JournalLasers in Medical Science
Volume36
Issue number2
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Diabetes mellitus
  • Fibroblasts
  • Hypoxic
  • Photobiomodulation
  • Signalling pathways
  • Wound healing

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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