TY - JOUR
T1 - Eco-friendly synthesis and characterizations of Ag/AgO/Ag2O nanoparticles using leaf extracts of Solanum elaeagnifolium for antioxidant, anticancer, and DNA cleavage activities
AU - Barwant, Mukul
AU - Ugale, Yogrsh
AU - Ghotekar, Suresh
AU - Basnet, Parita
AU - Nguyen, Van Huy
AU - Pansambal, Shreyas
AU - Ananda Murthy, H. C.
AU - Sillanpaa, Mika
AU - Bilal, Muhammad
AU - Oza, Rajeshwari
AU - Karande, Vanita
N1 - Publisher Copyright:
© 2022, Institute of Chemistry, Slovak Academy of Sciences.
PY - 2022/7
Y1 - 2022/7
N2 - The biogenic synthesis of nanoparticles (NPs) using a plant extract is rapid, simple, efficient, cost-effective, and eco-friendly. This study investigated selective pharmacological activities such as anticancer, antioxidant, and DNA cleavage of S. elaeagnifolium-mediated green synthesizing Ag/AgO/Ag2O NPs. To the best of our knowledge, S. elaeagnifolium has been the first time used to synthesize Ag/AgO/Ag2O NPs. The synthesized NPs were explored by using UV–Vis diffuse reflectance spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, and photoluminescence analyses. Anticancer activity of Ag/AgO/Ag2O NPs was tested on lung cancer cell lines (A-549) and showed activity at the IC50 of 67.09 μg/mL. The maximum 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were 25.78% and 20.86% at 100 µg/L, respectively. Moreover, S. elaeagnifolium-mediated green synthesized Ag/AgO/Ag2O NPs exhibited considerable DNA cleavage activity. These results assured that the synthesized Ag/AgO/Ag2O NPs using S. elaeagnifolium leaves extract may have potential applications in biomedical engineering. Graphical abstract: [Figure not available: see fulltext.]
AB - The biogenic synthesis of nanoparticles (NPs) using a plant extract is rapid, simple, efficient, cost-effective, and eco-friendly. This study investigated selective pharmacological activities such as anticancer, antioxidant, and DNA cleavage of S. elaeagnifolium-mediated green synthesizing Ag/AgO/Ag2O NPs. To the best of our knowledge, S. elaeagnifolium has been the first time used to synthesize Ag/AgO/Ag2O NPs. The synthesized NPs were explored by using UV–Vis diffuse reflectance spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, and photoluminescence analyses. Anticancer activity of Ag/AgO/Ag2O NPs was tested on lung cancer cell lines (A-549) and showed activity at the IC50 of 67.09 μg/mL. The maximum 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were 25.78% and 20.86% at 100 µg/L, respectively. Moreover, S. elaeagnifolium-mediated green synthesized Ag/AgO/Ag2O NPs exhibited considerable DNA cleavage activity. These results assured that the synthesized Ag/AgO/Ag2O NPs using S. elaeagnifolium leaves extract may have potential applications in biomedical engineering. Graphical abstract: [Figure not available: see fulltext.]
KW - Ag/AgO/AgO NPs
KW - Biomedical applications
KW - Green nanotechnology
KW - Solanum elaeagnifolium
UR - http://www.scopus.com/inward/record.url?scp=85127309786&partnerID=8YFLogxK
U2 - 10.1007/s11696-022-02178-0
DO - 10.1007/s11696-022-02178-0
M3 - Article
AN - SCOPUS:85127309786
SN - 0366-6352
VL - 76
SP - 4309
EP - 4321
JO - Chemical Papers
JF - Chemical Papers
IS - 7
ER -
