Dysregulated expression of miRNAs in immune thrombocytopenia

Abdollah Jafarzadeh; Havva Marzban; Maryam Nemati; Sara Jafarzadeh; Maryam Mahjoubin-Tehran; Michael R. Hamblin; Hamed Mirzaei; Hamid Reza Mirzaei

doi:10.2217/epi-2021-0092

Dysregulated expression of miRNAs in immune thrombocytopenia

Abdollah Jafarzadeh, Havva Marzban, Maryam Nemati, Sara Jafarzadeh, Maryam Mahjoubin-Tehran, Michael R. Hamblin, Hamed Mirzaei, Hamid Reza Mirzaei

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

Original language	English
Pages (from-to)	1315-1325
Number of pages	11
Journal	Epigenomics
Volume	13
Issue number	16
DOIs	https://doi.org/10.2217/epi-2021-0092
Publication status	Published - Aug 2021

Keywords

Diagnosis
Immune thrombocytopenia purpura
Pathogenesis
T cells
miRNA
noncoding RNAs

ASJC Scopus subject areas

Genetics
Cancer Research

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10.2217/epi-2021-0092

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title = "Dysregulated expression of miRNAs in immune thrombocytopenia",

abstract = "In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.",

keywords = "Diagnosis, Immune thrombocytopenia purpura, Pathogenesis, T cells, miRNA, noncoding RNAs",

author = "Abdollah Jafarzadeh and Havva Marzban and Maryam Nemati and Sara Jafarzadeh and Maryam Mahjoubin-Tehran and Hamblin, {Michael R.} and Hamed Mirzaei and Mirzaei, {Hamid Reza}",

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T1 - Dysregulated expression of miRNAs in immune thrombocytopenia

AU - Jafarzadeh, Abdollah

AU - Marzban, Havva

AU - Nemati, Maryam

AU - Jafarzadeh, Sara

AU - Mahjoubin-Tehran, Maryam

AU - Hamblin, Michael R.

AU - Mirzaei, Hamed

AU - Mirzaei, Hamid Reza

PY - 2021/8

Y1 - 2021/8

N2 - In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

AB - In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

KW - Diagnosis

KW - Immune thrombocytopenia purpura

KW - Pathogenesis

KW - T cells

KW - miRNA

KW - noncoding RNAs

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ER -

Dysregulated expression of miRNAs in immune thrombocytopenia

Abstract

Keywords

ASJC Scopus subject areas

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