Dysregulated expression of miRNAs in immune thrombocytopenia

Abdollah Jafarzadeh, Havva Marzban, Maryam Nemati, Sara Jafarzadeh, Maryam Mahjoubin-Tehran, Michael R. Hamblin, Hamed Mirzaei, Hamid Reza Mirzaei

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

Original languageEnglish
Pages (from-to)1315-1325
Number of pages11
JournalEpigenomics
Volume13
Issue number16
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Diagnosis
  • Immune thrombocytopenia purpura
  • Pathogenesis
  • T cells
  • miRNA
  • noncoding RNAs

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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