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Drug discovery of antimicrobial photosensitizers using animal models
Sulbha K. Sharma
, Tianhong Dai
, Gitika B. Kharkwal
, Ying Ying Huang
, Liyi Huang
, Vida J.Bil de Arce
, George P. Tegos
,
Michael R. Hamblin
Massachusetts General Hospital
Harvard University
Guangxi Medical University
University of New Mexico
Harvard-MIT Division of Health Sciences and Technology
Research output
:
Contribution to journal
›
Review article
›
peer-review
109
Citations (Scopus)
Overview
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Keyphrases
Alternative Antibiotics
11%
Antibiotic Discovery
11%
Antimicrobial Photodynamic Therapy (aPDT)
33%
Antimicrobial Photosensitizer
100%
Bacteriochlorin
11%
Biofilm Infection
11%
Bioluminescent
11%
Burned Skin
11%
Cationic Derivatives
11%
Cationic Liposomes
11%
Cationic Nanoparticles
11%
Cationic Photosensitizers
11%
Cationic Polymer
11%
Design Criteria
11%
Drug Design
11%
Drug Discovery
100%
Emerging Alternatives
11%
Excited States
11%
Fullerene Derivatives
11%
Fungi
11%
Gram-negative Bacteria
11%
Gram-positive
11%
High Absorption Coefficient
11%
High Photostability
11%
Hydroxyl Radical ([rad]OH)
11%
Imaging Systems
11%
In Vivo Efficacy
11%
Infected Area
11%
Infection Treatment
11%
Large-scale Structure
11%
Lethal Infection
11%
Light Penetration
11%
Localized Infection
11%
Long-lived
11%
Low-light Imaging
11%
Mammalian Cells
11%
Microbial Cells
33%
Molecular Classes
11%
Molecular Oxygen
11%
Mouse Model
11%
Multidrug-resistant Pathogens
11%
Nanoparticle Liposomes
11%
Near-infrared
11%
Oxygen Radicals
11%
Phenothiazine Dyes
11%
Photobleaching
11%
Photosensitizer
100%
Phthalocyanine
11%
Porphyrin
11%
Positive Charge
11%
Reactive Oxygen Species
11%
Singlet Oxygen
11%
Skin Abrasion
11%
Soft Tissue Abscess
11%
Tetrapyrrole
11%
Third-degree Burn
11%
Toxic Dyes
11%
Triplet State
11%
Pharmacology, Toxicology and Pharmaceutical Science
Abscess
9%
Antibiotics
9%
Antiinfective Agent
100%
Antimicrobial Agent
9%
Bacteriochlorin
9%
Burn
9%
Drug Development
9%
Drug Discovery
100%
Fullerene Derivative
9%
Gram Negative Bacterium
9%
Hydroxyl Radical
9%
Infection
63%
Infectious Agent
18%
Liposome
9%
Mouse Model
9%
Nanoparticle
9%
Oxygen Radical
9%
Photodynamic Therapy
27%
Photosensitizer
100%
Phthalocyanine
9%
Porphyrin
9%
Reactive Oxygen Metabolite
9%
Singlet Oxygen
9%
Skin Abrasion
9%
Tetrapyrrole Derivative
9%
Wound
9%