Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment

Tobeka Naki; W. Matshe; Philemon Ubanako; Samson A. Adeyemi; M. O. Balogun; S. Sinha Ray; Yahya E. Choonara; Blessing Atim Aderibigbe

doi:10.1080/25740881.2022.2029895

Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment

Tobeka Naki, W. Matshe, Philemon Ubanako, Samson A. Adeyemi, M. O. Balogun, S. Sinha Ray, Yahya E. Choonara, Blessing Atim Aderibigbe

Research output: Contribution to journal › Article › peer-review

Abstract

The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC₅₀ values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K₂PtCl₄ and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer.

Original language	English
Pages (from-to)	1003-1020
Number of pages	18
Journal	Polymer-Plastics Technology and Materials
Volume	61
Issue number	9
DOIs	https://doi.org/10.1080/25740881.2022.2029895
Publication status	Published - 2022
Externally published	Yes

Keywords

Platinum
cancer
dopamine
doxorubicin
polymer-drug conjugates
procaine

ASJC Scopus subject areas

General Chemical Engineering
Polymers and Plastics
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/25740881.2022.2029895

Cite this

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title = "Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment",

abstract = "The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC50 values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K2PtCl4 and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer.",

keywords = "Platinum, cancer, dopamine, doxorubicin, polymer-drug conjugates, procaine",

author = "Tobeka Naki and W. Matshe and Philemon Ubanako and Adeyemi, {Samson A.} and Balogun, {M. O.} and {Sinha Ray}, S. and Choonara, {Yahya E.} and Aderibigbe, {Blessing Atim}",

note = "Publisher Copyright: {\textcopyright} 2022 Taylor & Francis.",

year = "2022",

doi = "10.1080/25740881.2022.2029895",

language = "English",

volume = "61",

pages = "1003--1020",

journal = "Polymer-Plastics Technology and Materials",

issn = "2574-0881",

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}

TY - JOUR

T1 - Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment

AU - Naki, Tobeka

AU - Matshe, W.

AU - Ubanako, Philemon

AU - Adeyemi, Samson A.

AU - Balogun, M. O.

AU - Sinha Ray, S.

AU - Choonara, Yahya E.

AU - Aderibigbe, Blessing Atim

PY - 2022

Y1 - 2022

N2 - The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC50 values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K2PtCl4 and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer.

AB - The combination of dopamine with anticancer drugs can result in enhanced anticancer activity. Polymer-drug conjugates (PDCs) containing anticancer drugs, such as platinum-based drugs, and doxorubicin together with dopamine were prepared. PDCs were characterized followed by in vitro cytotoxicity studies using pheochromocytoma (PC12) cell lines. The particle size analysis revealed the particles sizes of the PDCs in the range of 15.68–179.8 nm with PDI in the range of 0.373–0.687. T3 and T6 displayed promising cytotoxic effects with IC50 values of 5.25 and 11.56 μg/mL when compared to the free drugs (29.65 μg/mL for K2PtCl4 and 14.96 μg/mL for procaine). The findings revealed that combining dopamine with anticancer drugs is a promising approach to develop effective therapeutics for the treatment of cancer.

KW - Platinum

KW - cancer

KW - dopamine

KW - doxorubicin

KW - polymer-drug conjugates

KW - procaine

UR - http://www.scopus.com/inward/record.url?scp=85123841215&partnerID=8YFLogxK

U2 - 10.1080/25740881.2022.2029895

DO - 10.1080/25740881.2022.2029895

M3 - Article

AN - SCOPUS:85123841215

SN - 2574-0881

VL - 61

SP - 1003

EP - 1020

JO - Polymer-Plastics Technology and Materials

JF - Polymer-Plastics Technology and Materials

IS - 9

ER -

Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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