TY - JOUR
T1 - Dissolvable wound dressing loaded with silver nanoparticles together with ampicillin and ciprofloxacin
AU - Ndlovu, Sindi Prescila
AU - Fonkui, Thierry Youmbi
AU - Ndinteh, Derek Tantoh
AU - Aderibigbe, Blessing Atim
N1 - Publisher Copyright:
© 2022 Newlands Press.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Aim: The current study is focused on the development of water-soluble wound dressings, which are potential dressings for the treatment of burn wounds. Materials & methods: Sodium alginate-based dissolvable wound dressings were prepared and loaded with silver nanoparticles and various antibiotics (ampicillin and ciprofloxacin) followed by characterization and in vitro antibacterial studies. Results & conclusions: The prepared sodium alginate-based dissolvable wound dressing exhibited good porosity, water uptake and moisture content, promising antibacterial activity, high absorption capacity of simulated wound exudates, excellent water vapor transmission rate in the range of 2000 to 5000 g/m2 day-1, sustained drug-release profiles and water solubility. The wound dressings were active against Proteus mirabilis, Staphylococcus aureus, Proteus vulgaris, Escherichia coli and Klebsiella aeruginosa strains of bacteria. The results obtained revealed the wound dressing as potential wound dressings for burn wounds and sensitive skin.
AB - Aim: The current study is focused on the development of water-soluble wound dressings, which are potential dressings for the treatment of burn wounds. Materials & methods: Sodium alginate-based dissolvable wound dressings were prepared and loaded with silver nanoparticles and various antibiotics (ampicillin and ciprofloxacin) followed by characterization and in vitro antibacterial studies. Results & conclusions: The prepared sodium alginate-based dissolvable wound dressing exhibited good porosity, water uptake and moisture content, promising antibacterial activity, high absorption capacity of simulated wound exudates, excellent water vapor transmission rate in the range of 2000 to 5000 g/m2 day-1, sustained drug-release profiles and water solubility. The wound dressings were active against Proteus mirabilis, Staphylococcus aureus, Proteus vulgaris, Escherichia coli and Klebsiella aeruginosa strains of bacteria. The results obtained revealed the wound dressing as potential wound dressings for burn wounds and sensitive skin.
KW - antibiotics
KW - burn wounds
KW - infections
KW - sodium alginate nanoparticles
KW - wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85136909745&partnerID=8YFLogxK
U2 - 10.4155/tde-2021-0087
DO - 10.4155/tde-2021-0087
M3 - Article
C2 - 35924677
AN - SCOPUS:85136909745
SN - 2041-5990
VL - 13
SP - 295
EP - 311
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 5
ER -