Abstract
The identification of cDNAs, representing up-regulated genes induced by lipopolysaccharides from Burkholderia cepacia, was achieved by differential display of mRNAs isolated from tobacco cells. In addition to up-regulation of superoxide dismutase, involved in the production of the signalling and defense molecule, hydrogen peroxide; differentially expressed cDNAs, indicative of the operation of an innate immune recognition system and expression of basal resistance, were identified. These include homologs to a receptor-like protein kinase; a binding protein for the type III secreted effector protein, harpin; a virus resistance N gene; an endogenous pararetrovirus and the Pto kinase. The altered gene expression may be responsible for activation of surveillance mechanisms and enhancement of the non-self recognition capacity. The putative roles of these transcripts in LPS-induced responses are discussed in relation to emerging concepts of innate immunity.
Original language | English |
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Pages (from-to) | 1001-1007 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 344 |
Issue number | 3 |
DOIs | |
Publication status | Published - 9 Jun 2006 |
Keywords
- Basal resistance
- Defense response
- Innate immunity
- Lipopolysaccharides (LPS)
- Pathogen-associated molecular pattern molecules (PAMPs)
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology