Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots

Vuyelwa Ncapayi; Neethu Ninan; Thabang C. Lebepe; Sundararajan Parani; Aswathy Ravindran Girija; Richard Bright; Krasimir Vasilev; Rodney Maluleke; Ncediwe Tsolekile; Tetsuya Kodama; Oluwatobi S. Oluwafemi

doi:10.3390/ijms222212514

Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots

Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Krasimir Vasilev, Rodney Maluleke, Ncediwe Tsolekile, Tetsuya Kodama, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

Original language	English
Article number	12514
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	22
DOIs	https://doi.org/10.3390/ijms222212514
Publication status	Published - 1 Nov 2021

Keywords

Bioimaging
Gram-negative bacteria
Gram-positive bacteria
Near infra-red quantum dots
Prostate cancer

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms222212514

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@article{24469ffa82384d62ad49416b0286409b,

title = "Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots",

abstract = "The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.",

keywords = "Bioimaging, Gram-negative bacteria, Gram-positive bacteria, Near infra-red quantum dots, Prostate cancer",

author = "Vuyelwa Ncapayi and Neethu Ninan and Lebepe, {Thabang C.} and Sundararajan Parani and Girija, {Aswathy Ravindran} and Richard Bright and Krasimir Vasilev and Rodney Maluleke and Ncediwe Tsolekile and Tetsuya Kodama and Oluwafemi, {Oluwatobi S.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

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doi = "10.3390/ijms222212514",

language = "English",

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T1 - Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots

AU - Ncapayi, Vuyelwa

AU - Ninan, Neethu

AU - Lebepe, Thabang C.

AU - Parani, Sundararajan

AU - Girija, Aswathy Ravindran

AU - Bright, Richard

AU - Vasilev, Krasimir

AU - Maluleke, Rodney

AU - Tsolekile, Ncediwe

AU - Kodama, Tetsuya

AU - Oluwafemi, Oluwatobi S.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

AB - The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

KW - Bioimaging

KW - Gram-negative bacteria

KW - Gram-positive bacteria

KW - Near infra-red quantum dots

KW - Prostate cancer

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DO - 10.3390/ijms222212514

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VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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