TY - JOUR
T1 - Development and Characterization of Curcumin Loaded Silver Nanoparticle Hydrogels for Antibacterial and Drug Delivery Applications
AU - Ravindra, Sakey
AU - Mulaba-Bafubiandi, Antoine F.
AU - Rajinikanth, V.
AU - Varaprasad, K.
AU - Narayana Reddy, N.
AU - Mohana Raju, K.
PY - 2012/11
Y1 - 2012/11
N2 - The present work involves the development of curcumin loaded silver hydrogel nanocomposites based on acrylamide and 2-acrylamido-2-methyl propanesulfonic acid, as a template by redox co-polymerization in the presence of hydrophilic crosslinker N,N 1-methylenebisacrylamide. Silver nitrate was taken as the metal precursor and sodium borohydride as a reducing agent. The formation of silver nanoparticles was monitored using UV-Vis absorption spectroscopy. The developed hydrogel silver nanocomposites (HSNC) were characterized by FTIR, UV-Vis, thermogravimetric analysis, scanning electron microscopy and transmission electron microscopy. The curcumin loading and release characteristics were performed for different hydrogel systems. The developed HSNCs were evaluated for preliminary antibacterial applications.
AB - The present work involves the development of curcumin loaded silver hydrogel nanocomposites based on acrylamide and 2-acrylamido-2-methyl propanesulfonic acid, as a template by redox co-polymerization in the presence of hydrophilic crosslinker N,N 1-methylenebisacrylamide. Silver nitrate was taken as the metal precursor and sodium borohydride as a reducing agent. The formation of silver nanoparticles was monitored using UV-Vis absorption spectroscopy. The developed hydrogel silver nanocomposites (HSNC) were characterized by FTIR, UV-Vis, thermogravimetric analysis, scanning electron microscopy and transmission electron microscopy. The curcumin loading and release characteristics were performed for different hydrogel systems. The developed HSNCs were evaluated for preliminary antibacterial applications.
KW - Antibacterial activity
KW - Hydrogel network
KW - Silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84867690263&partnerID=8YFLogxK
U2 - 10.1007/s10904-012-9734-4
DO - 10.1007/s10904-012-9734-4
M3 - Article
AN - SCOPUS:84867690263
SN - 1574-1443
VL - 22
SP - 1254
EP - 1262
JO - Journal of Inorganic and Organometallic Polymers and Materials
JF - Journal of Inorganic and Organometallic Polymers and Materials
IS - 6
ER -