TY - JOUR
T1 - Detection of Levofloxacin Using a Simple and Green Electrochemically Polymerized Glycine Layered Carbon Paste Electrode
AU - Bhimaraya, Kanthappa
AU - Manjunatha, Jamballi G.
AU - Moulya, Karnayana P.
AU - Tighezza, Ammar M.
AU - Albaqami, Munirah D.
AU - Sillanpää, Mika
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - The easy and rapid analytical tool, electrochemically polymerized (EP) glycine (GN) layered carbon paste electrode (LCPE), was used for the analysis of levofloxacin (LN) using cyclic voltammogram (CV) and differential pulse voltammetry (DPV). The surface features and activities of the electrochemical sensors EPGNLCPE and bare carbon paste electrode (BCPE) were analyzed using electrochemical impedance spectroscopy (EIS), field emission scanning electron microscopy (FE-SEM), CV and DPV methods. The modified sensor (EPGNLCPE)offers a vibrant and sensitive electrochemical LN oxidation peak by controlling overpotential and the electrode material fouling effect unlike BCPE. Under improved experimental conditions, the DPV method was used to analyze LN on EPGNLCPE by varying its concentration in 0.2 M phosphate buffer solution from 30 to 90 µM, resulting in a good linear relationship(between peak current and concentration), lower limit of detection (LOD: 8.436 × 10−7 M) and lower limit of quantification (LOQ: 2.812 × 10−6 M). Finally, real-time application of the sensor was tested by analyzing LN in medicinal samples, and good LN recovery was observed.
AB - The easy and rapid analytical tool, electrochemically polymerized (EP) glycine (GN) layered carbon paste electrode (LCPE), was used for the analysis of levofloxacin (LN) using cyclic voltammogram (CV) and differential pulse voltammetry (DPV). The surface features and activities of the electrochemical sensors EPGNLCPE and bare carbon paste electrode (BCPE) were analyzed using electrochemical impedance spectroscopy (EIS), field emission scanning electron microscopy (FE-SEM), CV and DPV methods. The modified sensor (EPGNLCPE)offers a vibrant and sensitive electrochemical LN oxidation peak by controlling overpotential and the electrode material fouling effect unlike BCPE. Under improved experimental conditions, the DPV method was used to analyze LN on EPGNLCPE by varying its concentration in 0.2 M phosphate buffer solution from 30 to 90 µM, resulting in a good linear relationship(between peak current and concentration), lower limit of detection (LOD: 8.436 × 10−7 M) and lower limit of quantification (LOQ: 2.812 × 10−6 M). Finally, real-time application of the sensor was tested by analyzing LN in medicinal samples, and good LN recovery was observed.
KW - carbon paste
KW - electrochemical analysis
KW - glycine
KW - levofloxacin
UR - http://www.scopus.com/inward/record.url?scp=85151152271&partnerID=8YFLogxK
U2 - 10.3390/chemosensors11030191
DO - 10.3390/chemosensors11030191
M3 - Article
AN - SCOPUS:85151152271
SN - 2227-9040
VL - 11
JO - Chemosensors
JF - Chemosensors
IS - 3
M1 - 191
ER -