Abstract
In situ-forming hydrogels have emerged as a versatile class of biomaterials with diverse applications in drug delivery (DD), tissue engineering, and regenerative medicine. The degradation kinetics of these hydrogels play a crucial role in determining their performance and efficacy in various biomedical applications. This chapter provides a comprehensive overview of the degradation mechanisms and kinetics of in situ-forming hydrogels, shedding light on their design, optimization, and potential for tailored therapeutic interventions. In addition, this chapter addresses the challenges associated with in situ-forming hydrogel degradation, such as potential toxic by-products and host responses. Strategies to mitigate these challenges and enhance the biocompatibility of hydrogels are discussed, with an emphasis on recent innovations in the field. Overall, this chapter offers a comprehensive and up-to-date overview of the degradation kinetics of in situ-forming hydrogels, providing valuable insights for researchers, clinicians, and engineers working in the field of biomaterials and DD. Understanding and controlling the degradation kinetics of these hydrogels is essential for the development of safe and effective therapeutic platforms, paving the way for innovative medical solutions and improved patient outcomes.
Original language | English |
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Title of host publication | Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery |
Publisher | Elsevier |
Pages | 499-518 |
Number of pages | 20 |
ISBN (Electronic) | 9780323991568 |
ISBN (Print) | 9780323993593 |
DOIs | |
Publication status | Published - 1 Jan 2024 |
Keywords
- Biomaterials
- Degradation kinetics
- Drug delivery
- In situ-forming hydrogels
- Polymer
ASJC Scopus subject areas
- General Engineering
- General Materials Science