TY - JOUR
T1 - Deciphering the role of LOC124905135-related non-coding RNA cluster in human cancers
T2 - A comprehensive review
AU - Eftekhari Kenzerki, Maryam
AU - Mohajeri Khorasani, Amirhossein
AU - Zare, Iman
AU - Amirmahani, Farzane
AU - Ghasemi, Younes
AU - Hamblin, Michael R.
AU - Mousavi, Pegah
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/11/30
Y1 - 2024/11/30
N2 - Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long ncRNAs (lncRNAs), are essential regulators of processes, such as the cell cycle and apoptosis. In addition to interacting with intracellular complexes and participating in diverse molecular pathways, ncRNAs can be used as clinical diagnostic biomarkers and therapeutic targets for fighting cancer. Studying ncRNA gene clusters is crucial for understanding their role in cancer and developing new treatments. LOC124905135 is a protein-coding gene encoding a collagen alpha-1(III) chain-like protein, and also acts as a gene for several ncRNAs, including miR-3619, PRR34 antisense RNA 1 (PRR34-AS1), PRR34, long intergenic ncRNA 2939 (LINC02939), LOC112268288, and MIRLET7BHG. It also serves as a host gene for three miRNAs (hsa-let7-A3, hsa-miR-4763, and hsa-let-7b). Notably, the ncRNAs derived from this particular genomic region significantly affect various cell functions, including the cell cycle and apoptosis. This cluster of ncRNAs is dysregulated in several types of cancer, exhibiting mutations, alterations in copy number, and being subject to DNA methylation and histone modification. In summary, the ncRNAs derived from the LOC124905135 cluster could be used as targets for diagnosis, therapy monitoring, and drug discovery in human cancers.
AB - Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long ncRNAs (lncRNAs), are essential regulators of processes, such as the cell cycle and apoptosis. In addition to interacting with intracellular complexes and participating in diverse molecular pathways, ncRNAs can be used as clinical diagnostic biomarkers and therapeutic targets for fighting cancer. Studying ncRNA gene clusters is crucial for understanding their role in cancer and developing new treatments. LOC124905135 is a protein-coding gene encoding a collagen alpha-1(III) chain-like protein, and also acts as a gene for several ncRNAs, including miR-3619, PRR34 antisense RNA 1 (PRR34-AS1), PRR34, long intergenic ncRNA 2939 (LINC02939), LOC112268288, and MIRLET7BHG. It also serves as a host gene for three miRNAs (hsa-let7-A3, hsa-miR-4763, and hsa-let-7b). Notably, the ncRNAs derived from this particular genomic region significantly affect various cell functions, including the cell cycle and apoptosis. This cluster of ncRNAs is dysregulated in several types of cancer, exhibiting mutations, alterations in copy number, and being subject to DNA methylation and histone modification. In summary, the ncRNAs derived from the LOC124905135 cluster could be used as targets for diagnosis, therapy monitoring, and drug discovery in human cancers.
KW - LOC124905135
KW - Long non-coding RNAs
KW - MicroRNAs
KW - Oncogenes
KW - Prognosis
KW - Tumor suppressor gene
UR - http://www.scopus.com/inward/record.url?scp=85209563644&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2024.e39931
DO - 10.1016/j.heliyon.2024.e39931
M3 - Review article
AN - SCOPUS:85209563644
SN - 2405-8440
VL - 10
JO - Heliyon
JF - Heliyon
IS - 22
M1 - e39931
ER -
