Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells

L. Huang; M. Wang; S. K. Sharma; F. F. Sperandio; S. Maragani; S. Naykaa; J. Chang; M. R. Hamblin; L. Y. Chiang

doi:10.1149/04520.0065ecst

Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells

L. Huang
, M. Wang
, S. K. Sharma
, F. F. Sperandio
, S. Maragani
, S. Naykaa
, J. Chang
, M. R. Hamblin
, L. Y. Chiang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

13 Citations (Scopus)

Abstract

Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C₆₀[>M(C ₃N₆ +C₃)₂] and C₇₀[> M(C₃N₆+C₃)₂], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C₇₀[> M(C₃N₆ +C₃)₂] produced more highly reactive HO radical than C₆₀[>M(C₃N₆ +C ₃)₂], in addition to singlet oxygen (¹O ₂). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C₆₀[>M(C ₃N₆ +C₃)₂] and C₇₀[> M(C₃N₆ +C₃)₂], respectively. The hypothesis is that ¹O₂ can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO to cause real damage.

Original language	English
Title of host publication	Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting
Publisher	Electrochemical Society Inc.
Pages	65-73
Number of pages	9
Edition	20
ISBN (Electronic)	9781623320362
ISBN (Print)	9781623320362
DOIs	https://doi.org/10.1149/04520.0065ecst
Publication status	Published - 2012
Externally published	Yes
Event	Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting - Seattle, WA, United States Duration: 6 May 2012 → 10 May 2012

Publication series

Name	ECS Transactions
Number	20
Volume	45
ISSN (Print)	1938-5862
ISSN (Electronic)	1938-6737

Conference

Conference	Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting
Country/Territory	United States
City	Seattle, WA
Period	6/05/12 → 10/05/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Engineering

Access to Document

10.1149/04520.0065ecst

Cite this

Huang, L., Wang, M., Sharma, S. K., Sperandio, F. F., Maragani, S., Naykaa, S., Chang, J., Hamblin, M. R., & Chiang, L. Y. (2012). Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells. In Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting (20 ed., pp. 65-73). (ECS Transactions; Vol. 45, No. 20). Electrochemical Society Inc.. https://doi.org/10.1149/04520.0065ecst

@inproceedings{0bfe887005444d27961d2106da80ca4b,

title = "Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells",

abstract = "Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C 3N6 +C3)2] and C70[> M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[> M(C3N6 +C3)2] produced more highly reactive HO radical than C60[>M(C3N6 +C 3)2], in addition to singlet oxygen (1O 2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C 3N6 +C3)2] and C70[> M(C3N6 +C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO to cause real damage.",

author = "L. Huang and M. Wang and Sharma, \{S. K.\} and Sperandio, \{F. F.\} and S. Maragani and S. Naykaa and J. Chang and Hamblin, \{M. R.\} and Chiang, \{L. Y.\}",

year = "2012",

doi = "10.1149/04520.0065ecst",

language = "English",

isbn = "9781623320362",

series = "ECS Transactions",

publisher = "Electrochemical Society Inc.",

number = "20",

pages = "65--73",

booktitle = "Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting",

edition = "20",

note = "Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting ; Conference date: 06-05-2012 Through 10-05-2012",

}

Huang, L, Wang, M, Sharma, SK, Sperandio, FF, Maragani, S, Naykaa, S, Chang, J, Hamblin, MR & Chiang, LY 2012, Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells. in Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting. 20 edn, ECS Transactions, no. 20, vol. 45, Electrochemical Society Inc., pp. 65-73, Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting, Seattle, WA, United States, 6/05/12. https://doi.org/10.1149/04520.0065ecst

Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells. / Huang, L.; Wang, M.; Sharma, S. K. et al.
Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting. 20. ed. Electrochemical Society Inc., 2012. p. 65-73 (ECS Transactions; Vol. 45, No. 20).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells

AU - Huang, L.

AU - Wang, M.

AU - Sharma, S. K.

AU - Sperandio, F. F.

AU - Maragani, S.

AU - Naykaa, S.

AU - Chang, J.

AU - Hamblin, M. R.

AU - Chiang, L. Y.

PY - 2012

Y1 - 2012

N2 - Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C 3N6 +C3)2] and C70[> M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[> M(C3N6 +C3)2] produced more highly reactive HO radical than C60[>M(C3N6 +C 3)2], in addition to singlet oxygen (1O 2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C 3N6 +C3)2] and C70[> M(C3N6 +C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO to cause real damage.

AB - Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C 3N6 +C3)2] and C70[> M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[> M(C3N6 +C3)2] produced more highly reactive HO radical than C60[>M(C3N6 +C 3)2], in addition to singlet oxygen (1O 2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C 3N6 +C3)2] and C70[> M(C3N6 +C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO to cause real damage.

UR - https://www.scopus.com/pages/publications/84885759159

U2 - 10.1149/04520.0065ecst

DO - 10.1149/04520.0065ecst

M3 - Conference contribution

AN - SCOPUS:84885759159

SN - 9781623320362

T3 - ECS Transactions

SP - 65

EP - 73

BT - Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting

PB - Electrochemical Society Inc.

T2 - Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting

Y2 - 6 May 2012 through 10 May 2012

ER -

Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells

Abstract

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