@inproceedings{0bfe887005444d27961d2106da80ca4b,
title = "Decacationic [70]fullerene approach for efficient photokilling of infectious bacteria and cancer cells",
abstract = "Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C 3N6 +C3)2] and C70[> M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[> M(C3N6 +C3)2] produced more highly reactive HO radical than C60[>M(C3N6 +C 3)2], in addition to singlet oxygen (1O 2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C 3N6 +C3)2] and C70[> M(C3N6 +C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO to cause real damage.",
author = "L. Huang and M. Wang and Sharma, {S. K.} and Sperandio, {F. F.} and S. Maragani and S. Naykaa and J. Chang and Hamblin, {M. R.} and Chiang, {L. Y.}",
year = "2012",
doi = "10.1149/04520.0065ecst",
language = "English",
isbn = "9781623320362",
series = "ECS Transactions",
publisher = "Electrochemical Society Inc.",
number = "20",
pages = "65--73",
booktitle = "Fullerenes, Nanotubes, and Carbon Nanostructures - 221st ECS Meeting",
edition = "20",
note = "Fullerenes, Nanotubes, and Carbon Nanostructures - Symposium on Electron Transfer and Energy Applications of Fullerenes and Nanostructured Materials, Carbon Nanotubes and Nanostructures - 221st ECS Meeting ; Conference date: 06-05-2012 Through 10-05-2012",
}
