Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells

Thabang C. Lebepe; Sundararajan Parani; Ncapayi Vuyelwa; Tetsuya Kodama; Oluwatobi S. Oluwafemi

doi:10.1016/j.matlet.2020.128470

Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells

Thabang C. Lebepe, Sundararajan Parani, Ncapayi Vuyelwa, Tetsuya Kodama, Oluwatobi S. Oluwafemi

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Graphene oxide (GO) has been very useful in many applications however little is known about its toxicity in biological applications. Herein, we report the synthesis of GO and its cytotoxicity against four cancer (adherent and suspension) cell lines namely fibroblast histiocytoma (KM-Luc/GFP), breast (FM3A-Luc), ovarian (OV 2944-HM-1) and fibrosarcoma (NFSaY83). The as-synthesized GO is highly dispersible in water with good optical and structural properties. The cytotoxicity evaluation indicated that the as-prepared GO displayed high cell viability against all the four cancer cell lines and its action was very selective at very high concentration (500 µg/mL) with no significant toxicity towards FM3A-Luc and OV 2944-HM-1 at all concentrations.

Original language	English
Article number	128470
Journal	Materials Letters
Volume	279
DOIs	https://doi.org/10.1016/j.matlet.2020.128470
Publication status	Published - 15 Nov 2020

Keywords

Cancer cell lines
Cytotoxicity
Graphene oxide
Hummer's method

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.matlet.2020.128470

Cite this

@article{72ef27d581c24977b9b384a17cd77f91,

title = "Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells",

abstract = "Graphene oxide (GO) has been very useful in many applications however little is known about its toxicity in biological applications. Herein, we report the synthesis of GO and its cytotoxicity against four cancer (adherent and suspension) cell lines namely fibroblast histiocytoma (KM-Luc/GFP), breast (FM3A-Luc), ovarian (OV 2944-HM-1) and fibrosarcoma (NFSaY83). The as-synthesized GO is highly dispersible in water with good optical and structural properties. The cytotoxicity evaluation indicated that the as-prepared GO displayed high cell viability against all the four cancer cell lines and its action was very selective at very high concentration (500 µg/mL) with no significant toxicity towards FM3A-Luc and OV 2944-HM-1 at all concentrations.",

keywords = "Cancer cell lines, Cytotoxicity, Graphene oxide, Hummer's method",

author = "Lebepe, {Thabang C.} and Sundararajan Parani and Ncapayi Vuyelwa and Tetsuya Kodama and Oluwafemi, {Oluwatobi S.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = nov,

day = "15",

doi = "10.1016/j.matlet.2020.128470",

language = "English",

volume = "279",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells

AU - Lebepe, Thabang C.

AU - Parani, Sundararajan

AU - Vuyelwa, Ncapayi

AU - Kodama, Tetsuya

AU - Oluwafemi, Oluwatobi S.

PY - 2020/11/15

Y1 - 2020/11/15

N2 - Graphene oxide (GO) has been very useful in many applications however little is known about its toxicity in biological applications. Herein, we report the synthesis of GO and its cytotoxicity against four cancer (adherent and suspension) cell lines namely fibroblast histiocytoma (KM-Luc/GFP), breast (FM3A-Luc), ovarian (OV 2944-HM-1) and fibrosarcoma (NFSaY83). The as-synthesized GO is highly dispersible in water with good optical and structural properties. The cytotoxicity evaluation indicated that the as-prepared GO displayed high cell viability against all the four cancer cell lines and its action was very selective at very high concentration (500 µg/mL) with no significant toxicity towards FM3A-Luc and OV 2944-HM-1 at all concentrations.

AB - Graphene oxide (GO) has been very useful in many applications however little is known about its toxicity in biological applications. Herein, we report the synthesis of GO and its cytotoxicity against four cancer (adherent and suspension) cell lines namely fibroblast histiocytoma (KM-Luc/GFP), breast (FM3A-Luc), ovarian (OV 2944-HM-1) and fibrosarcoma (NFSaY83). The as-synthesized GO is highly dispersible in water with good optical and structural properties. The cytotoxicity evaluation indicated that the as-prepared GO displayed high cell viability against all the four cancer cell lines and its action was very selective at very high concentration (500 µg/mL) with no significant toxicity towards FM3A-Luc and OV 2944-HM-1 at all concentrations.

KW - Cancer cell lines

KW - Cytotoxicity

KW - Graphene oxide

KW - Hummer's method

UR - http://www.scopus.com/inward/record.url?scp=85089218801&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2020.128470

DO - 10.1016/j.matlet.2020.128470

M3 - Article

AN - SCOPUS:85089218801

SN - 0167-577X

VL - 279

JO - Materials Letters

JF - Materials Letters

M1 - 128470

ER -

Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this