Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Phi Hung Nguyen; Thi Van Thu Le; Phuong Thien Thuong; Trong Tuan Dao; Derek Tantoh Ndinteh; Joseph Tanyi Mbafor; Keon Wook Kang; Won Keun Oh

doi:10.1016/j.bmcl.2009.09.108

Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Phi Hung Nguyen
, Thi Van Thu Le
, Phuong Thien Thuong
, Trong Tuan Dao
, Derek Tantoh Ndinteh
, Joseph Tanyi Mbafor
, Keon Wook Kang
, Won Keun Oh

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]_D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC₅₀ values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC₅₀ values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.

Original language	English
Pages (from-to)	6745-6749
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2009.09.108
Publication status	Published - 1 Dec 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer cell line
Cytotoxic activity
Erythrina abyssinica
Leguminosae
Protein tyrosine phosphatase-1B (PTP1B)
Pterocarpan derivatives

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.09.108

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title = "Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica",

abstract = "Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC50 values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC50 values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.",

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doi = "10.1016/j.bmcl.2009.09.108",

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T1 - Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

AU - Nguyen, Phi Hung

AU - Le, Thi Van Thu

AU - Thuong, Phuong Thien

AU - Dao, Trong Tuan

AU - Ndinteh, Derek Tantoh

AU - Mbafor, Joseph Tanyi

AU - Kang, Keon Wook

AU - Oh, Won Keun

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AB - Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC50 values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC50 values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.

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KW - Cytotoxic activity

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KW - Leguminosae

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KW - Pterocarpan derivatives

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M3 - Article

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ER -

Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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