Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Phi Hung Nguyen; Thi Van Thu Le; Phuong Thien Thuong; Trong Tuan Dao; Derek Tantoh Ndinteh; Joseph Tanyi Mbafor; Keon Wook Kang; Won Keun Oh

doi:10.1016/j.bmcl.2009.09.108

Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Phi Hung Nguyen, Thi Van Thu Le, Phuong Thien Thuong, Trong Tuan Dao, Derek Tantoh Ndinteh, Joseph Tanyi Mbafor, Keon Wook Kang, Won Keun Oh

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]_D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC₅₀ values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC₅₀ values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.

Original language	English
Pages (from-to)	6745-6749
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2009.09.108
Publication status	Published - 1 Dec 2009
Externally published	Yes

Keywords

Breast cancer cell line
Cytotoxic activity
Erythrina abyssinica
Leguminosae
Protein tyrosine phosphatase-1B (PTP1B)
Pterocarpan derivatives

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.09.108

Cite this

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title = "Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica",

abstract = "Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [α]D, CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC50 values ranging from 4.2 ± 0.2 to 19.3 ± 0.3 μM) showed strong cytotoxic activity (IC50 values from 5.6 ± 0.7 to 28.0 ± 0.2 μM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.",

keywords = "Breast cancer cell line, Cytotoxic activity, Erythrina abyssinica, Leguminosae, Protein tyrosine phosphatase-1B (PTP1B), Pterocarpan derivatives",

author = "Nguyen, {Phi Hung} and Le, {Thi Van Thu} and Thuong, {Phuong Thien} and Dao, {Trong Tuan} and Ndinteh, {Derek Tantoh} and Mbafor, {Joseph Tanyi} and Kang, {Keon Wook} and Oh, {Won Keun}",

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doi = "10.1016/j.bmcl.2009.09.108",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

AU - Nguyen, Phi Hung

AU - Le, Thi Van Thu

AU - Thuong, Phuong Thien

AU - Dao, Trong Tuan

AU - Ndinteh, Derek Tantoh

AU - Mbafor, Joseph Tanyi

AU - Kang, Keon Wook

AU - Oh, Won Keun

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KW - Leguminosae

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Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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