Cytokines and microRNAs in SARS-CoV-2: What do we know?

Fahimeh Zamani Rarani; Bahman Rashidi; Mohammad Hassan Jafari Najaf Abadi; Michael R. Hamblin; Seyed Mohammad Reza Hashemian; Hamed Mirzaei

doi:10.1016/j.omtn.2022.06.017

Cytokines and microRNAs in SARS-CoV-2: What do we know?

Fahimeh Zamani Rarani, Bahman Rashidi, Mohammad Hassan Jafari Najaf Abadi, Michael R. Hamblin, Seyed Mohammad Reza Hashemian, Hamed Mirzaei

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

The coronavirus disease 2019 (COVID-19) pandemic constitutes a global health emergency. Currently, there are no completely effective therapeutic medications for the management of this outbreak. The cytokine storm is a hyperinflammatory medical condition due to excessive and uncontrolled release of pro-inflammatory cytokines in patients suffering from severe COVID-19, leading to the development of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) and even mortality. Understanding the pathophysiology of COVID-19 can be helpful for the treatment of patients. Evidence suggests that the levels of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1 and IL-6 are dramatically different between mild and severe patients, so they may be important contributors to the cytokine storm. Several serum markers can be predictors for the cytokine storm. This review discusses the cytokines involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, focusing on interferons (IFNs) and ILs, and whether they can be used in COVID-19 treatment. Moreover, we highlight several microRNAs that are involved in these cytokines and their role in the cytokine storm caused by COVID-19.

Original language	English
Pages (from-to)	219-242
Number of pages	24
Journal	Molecular Therapy - Nucleic Acids
Volume	29
DOIs	https://doi.org/10.1016/j.omtn.2022.06.017
Publication status	Published - 13 Sept 2022

Keywords

COVID-19
Janus kinases
NF-κB
SARS-CoV-2
STAT transcription factors
cytokines
interferons
interleukins
microRNAs

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.omtn.2022.06.017

Cite this

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title = "Cytokines and microRNAs in SARS-CoV-2: What do we know?",

abstract = "The coronavirus disease 2019 (COVID-19) pandemic constitutes a global health emergency. Currently, there are no completely effective therapeutic medications for the management of this outbreak. The cytokine storm is a hyperinflammatory medical condition due to excessive and uncontrolled release of pro-inflammatory cytokines in patients suffering from severe COVID-19, leading to the development of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) and even mortality. Understanding the pathophysiology of COVID-19 can be helpful for the treatment of patients. Evidence suggests that the levels of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1 and IL-6 are dramatically different between mild and severe patients, so they may be important contributors to the cytokine storm. Several serum markers can be predictors for the cytokine storm. This review discusses the cytokines involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, focusing on interferons (IFNs) and ILs, and whether they can be used in COVID-19 treatment. Moreover, we highlight several microRNAs that are involved in these cytokines and their role in the cytokine storm caused by COVID-19.",

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AU - Hamblin, Michael R.

AU - Reza Hashemian, Seyed Mohammad

AU - Mirzaei, Hamed

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AB - The coronavirus disease 2019 (COVID-19) pandemic constitutes a global health emergency. Currently, there are no completely effective therapeutic medications for the management of this outbreak. The cytokine storm is a hyperinflammatory medical condition due to excessive and uncontrolled release of pro-inflammatory cytokines in patients suffering from severe COVID-19, leading to the development of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) and even mortality. Understanding the pathophysiology of COVID-19 can be helpful for the treatment of patients. Evidence suggests that the levels of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1 and IL-6 are dramatically different between mild and severe patients, so they may be important contributors to the cytokine storm. Several serum markers can be predictors for the cytokine storm. This review discusses the cytokines involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, focusing on interferons (IFNs) and ILs, and whether they can be used in COVID-19 treatment. Moreover, we highlight several microRNAs that are involved in these cytokines and their role in the cytokine storm caused by COVID-19.

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Cytokines and microRNAs in SARS-CoV-2: What do we know?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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