Cytokines and COVID-19: friends or foes?

Mohsen Rokni; Michael R. Hamblin; Nima Rezaei

doi:10.1080/21645515.2020.1799669

Cytokines and COVID-19: friends or foes?

Mohsen Rokni, Michael R. Hamblin, Nima Rezaei

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Original language	English
Pages (from-to)	2363-2365
Number of pages	3
Journal	Human Vaccines and Immunotherapeutics
Volume	16
Issue number	10
DOIs	https://doi.org/10.1080/21645515.2020.1799669
Publication status	Published - 2 Oct 2020
Externally published	Yes

Keywords

COVID-19
Cytokine storm
chemokines
pro-inflammatory cytokines
severe acute respiratory syndrome coronavirus 2

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21645515.2020.1799669

Cite this

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title = "Cytokines and COVID-19: friends or foes?",

abstract = "The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).",

keywords = "COVID-19, Cytokine storm, chemokines, pro-inflammatory cytokines, severe acute respiratory syndrome coronavirus 2",

author = "Mohsen Rokni and Hamblin, \{Michael R.\} and Nima Rezaei",

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year = "2020",

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doi = "10.1080/21645515.2020.1799669",

language = "English",

volume = "16",

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journal = "Human Vaccines and Immunotherapeutics",

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T1 - Cytokines and COVID-19

T2 - friends or foes?

AU - Rokni, Mohsen

AU - Hamblin, Michael R.

AU - Rezaei, Nima

PY - 2020/10/2

Y1 - 2020/10/2

N2 - The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

AB - The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

KW - COVID-19

KW - Cytokine storm

KW - chemokines

KW - pro-inflammatory cytokines

KW - severe acute respiratory syndrome coronavirus 2

UR - https://www.scopus.com/pages/publications/85089860415

U2 - 10.1080/21645515.2020.1799669

DO - 10.1080/21645515.2020.1799669

M3 - Article

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AN - SCOPUS:85089860415

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VL - 16

SP - 2363

EP - 2365

JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

IS - 10

ER -

Cytokines and COVID-19: friends or foes?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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