Cyclopiamines A and B, novel oxindole metabolites of penicillium cyclopium Westling

Roy F. Bond, Jan C.A. Boeyens, Cedric W. Holzapfel, Pieter S. Steyn

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

The isolation of two new oxindole alkaloids, cyclopiamine A and B, from Penicillium cyclopium is described. The chemical and spectral properties of cyclopiamine B are interpreted in terms of the constitution and relative stereochemistry (2a) of the compound as determined by X-ray structure analysis. The enantiomeric relationship between cyclopiamine A(1) and B(2a) at C(22) is established on the basis of chemical studies.

Original languageEnglish
Pages (from-to)1751-1761
Number of pages11
JournalJournal of the Chemical Society, Perkin Transactions 1
DOIs
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry

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