Cutaneous sporotrichosis treated with photodynamic therapy: An in vitro and in vivo study

Yolanda Gilaberte; Carmen Aspiroz; M. Carmen Alejandre; Elena Andres-Ciriano; Blanca Fortuño; Luis Charlez; Maria Jose Revillo; Michael R. Hamblin; Antonio Rezusta

doi:10.1089/pho.2013.3590

Cutaneous sporotrichosis treated with photodynamic therapy: An in vitro and in vivo study

Yolanda Gilaberte
, Carmen Aspiroz
, M. Carmen Alejandre
, Elena Andres-Ciriano
, Blanca Fortuño
, Luis Charlez
, Maria Jose Revillo
, Michael R. Hamblin
, Antonio Rezusta

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix^®)- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.

Original language	English
Pages (from-to)	54-57
Number of pages	4
Journal	Photomedicine and Laser Surgery
Volume	32
Issue number	1
DOIs	https://doi.org/10.1089/pho.2013.3590
Publication status	Published - 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biomedical Engineering
Radiology, Nuclear Medicine and Imaging

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10.1089/pho.2013.3590

Cite this

@article{7601f33b4ab549939790262e4eaa10ae,

title = "Cutaneous sporotrichosis treated with photodynamic therapy: An in vitro and in vivo study",

abstract = "Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16\% methyl aminolevulinate (MAL, Metvix{\textregistered})- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1\% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.",

author = "Yolanda Gilaberte and Carmen Aspiroz and \{Carmen Alejandre\}, M. and Elena Andres-Ciriano and Blanca Fortu{\~n}o and Luis Charlez and Revillo, \{Maria Jose\} and Hamblin, \{Michael R.\} and Antonio Rezusta",

year = "2014",

doi = "10.1089/pho.2013.3590",

language = "English",

volume = "32",

pages = "54--57",

journal = "Photomedicine and Laser Surgery",

issn = "1549-5418",

publisher = "Mary Ann Liebert Inc.",

number = "1",

}

TY - JOUR

T1 - Cutaneous sporotrichosis treated with photodynamic therapy

T2 - An in vitro and in vivo study

AU - Gilaberte, Yolanda

AU - Aspiroz, Carmen

AU - Carmen Alejandre, M.

AU - Andres-Ciriano, Elena

AU - Fortuño, Blanca

AU - Charlez, Luis

AU - Revillo, Maria Jose

AU - Hamblin, Michael R.

AU - Rezusta, Antonio

PY - 2014

Y1 - 2014

N2 - Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix®)- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.

AB - Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix®)- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.

UR - https://www.scopus.com/pages/publications/84891870104

U2 - 10.1089/pho.2013.3590

DO - 10.1089/pho.2013.3590

M3 - Article

C2 - 24328608

AN - SCOPUS:84891870104

SN - 1549-5418

VL - 32

SP - 54

EP - 57

JO - Photomedicine and Laser Surgery

JF - Photomedicine and Laser Surgery

IS - 1

ER -

Cutaneous sporotrichosis treated with photodynamic therapy: An in vitro and in vivo study

Abstract

UN SDGs

ASJC Scopus subject areas

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