TY - JOUR
T1 - Cutaneous sporotrichosis treated with photodynamic therapy
T2 - An in vitro and in vivo study
AU - Gilaberte, Yolanda
AU - Aspiroz, Carmen
AU - Carmen Alejandre, M.
AU - Andres-Ciriano, Elena
AU - Fortuño, Blanca
AU - Charlez, Luis
AU - Revillo, Maria Jose
AU - Hamblin, Michael R.
AU - Rezusta, Antonio
PY - 2014
Y1 - 2014
N2 - Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix®)- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.
AB - Background: Sporotrichosis is a fungal infection caused by Sporothrix schenckii complex, usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. Antimicrobial photodynamic therapy (aPDT) could be a good alternative to manage localized, superficial infections. Case report: A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. Topical 16% methyl aminolevulinate (MAL, Metvix®)- PDT was used without success. Methods: An in vitro photoinactivation test with the isolated microorganism revealed phenothiazinium salts to be more effective than MAL. Conclusions: PDT with intralesional 1% methylene blue (MB) in combination with intermittent low doses of itraconazole obtained complete microbiological and clinical response.
UR - http://www.scopus.com/inward/record.url?scp=84891870104&partnerID=8YFLogxK
U2 - 10.1089/pho.2013.3590
DO - 10.1089/pho.2013.3590
M3 - Article
C2 - 24328608
AN - SCOPUS:84891870104
SN - 1549-5418
VL - 32
SP - 54
EP - 57
JO - Photomedicine and Laser Surgery
JF - Photomedicine and Laser Surgery
IS - 1
ER -
