Curcumin and Gymnema sylvestre extract loaded graphene oxide-polyhydroxybutyrate‑sodium alginate composite for diabetic wound regeneration

Current treatment for diabetic wounds remains a major clinical challenge. The present work was aimed at the fabrication of a novel scaffold consisting of curcumin and Gymnema sylvestre incorporated graphene oxide-polyhydroxybutyrate‑sodium alginate (GO-PHB-SA-CUR&GS) composite as an extracellular matrix platform. The novel graphene oxide-polyhydroxybutyrate‑sodium alginate composite scaffold was prepared by solution casting, into which curcumin and Gymnema sylvestre was incorporated to improve healing of normal and diabetic wounds for better tissue regeneration application. The GO-PHB-SA-CUR&GS composite was evaluated for particle size, surface charge (zeta potential), crystalline nature (XRD), and morphology (SEM). In-vitro studies with normal and diabetic fibroblast cells confirmed that the GO-PHB-SA-CUR&GS composite showed good biocompatible characteristics in terms of increased migration of wounded cells. Thus, the GO-PHB-SA-CUR&GS composite could significantly accelerate the healing of normal and diabetic wounds.