Comparison between local abdominal and transcutaneous tail vein photobiomodulation in experimental rat model of ulcerative colitis

Virgínia Mendes Matias Rodrigues, Kelly Cristina Quintela Martins Bitencourt, Adriana Schapochnik, Vanessa de Souza, Marlon da Palma Cruz, Amílcar Sabino Damazo, Caroline Marcantonio Ferreira, Rebeca Boltes Cecatto, Michael R. Hamblin, Maria Fernanda Setúlbal Destro Rodrigues, Adriana Lino-dos-Santos-Franco

Research output: Contribution to journalArticlepeer-review

Abstract

Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.

Original languageEnglish
Article number247
JournalLasers in Medical Science
Volume38
Issue number1
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Cytokines
  • Local abdominal photobiomodulation
  • Rat model
  • Transcutaneous vascular photobiomodulation
  • Ulcerative colitis

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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