TY - JOUR
T1 - Comparison between local abdominal and transcutaneous tail vein photobiomodulation in experimental rat model of ulcerative colitis
AU - Rodrigues, Virgínia Mendes Matias
AU - Bitencourt, Kelly Cristina Quintela Martins
AU - Schapochnik, Adriana
AU - de Souza, Vanessa
AU - da Palma Cruz, Marlon
AU - Damazo, Amílcar Sabino
AU - Ferreira, Caroline Marcantonio
AU - Cecatto, Rebeca Boltes
AU - Hamblin, Michael R.
AU - Destro Rodrigues, Maria Fernanda Setúlbal
AU - Lino-dos-Santos-Franco, Adriana
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.
AB - Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.
KW - Cytokines
KW - Local abdominal photobiomodulation
KW - Rat model
KW - Transcutaneous vascular photobiomodulation
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85175189527&partnerID=8YFLogxK
U2 - 10.1007/s10103-023-03910-2
DO - 10.1007/s10103-023-03910-2
M3 - Article
C2 - 37897531
AN - SCOPUS:85175189527
SN - 0268-8921
VL - 38
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 1
M1 - 247
ER -